Gene
glrx2
- ID
- ZDB-GENE-040718-101
- Name
- glutaredoxin 2
- Symbol
- glrx2 Nomenclature History
- Previous Names
-
- grx2 (1)
- zgc:92698
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables 2 iron, 2 sulfur cluster binding activity and glutathione disulfide oxidoreductase activity. Acts upstream of or within circulatory system development; nervous system development; and protein deglutathionylation. Located in cytosol. Is expressed in neurons. Orthologous to human GLRX2 (glutaredoxin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92698 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37514 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutaredoxin | Glutaredoxin active site | Glutaredoxin, eukaryotic/virial | Glutaredoxin subgroup | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DH06 | InterPro PDB | 134 | |||||
| UniProtKB:A0A8M2B8M4 | InterPro | 157 | |||||
| UniProtKB:A0A0R4IXU6 | InterPro | 152 | |||||
| UniProtKB:A0A0R4ILJ8 | InterPro | 170 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:glrx2) |
|
| 1 | Wilms et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-13N19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-53B10 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-390F18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92698 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002404 (1) | 876 nt | ||
| Genomic | GenBank:BX936311 (1) | 192750 nt | ||
| Polypeptide | UniProtKB:A0A0R4ILJ8 (1) | 170 aa |
- Wilms, C., Lepka, K., Häberlein, F., Edwards, S., Felsberg, J., Pudelko, L., Lindenberg, T.T., Poschmann, G., Qin, N., Volbracht, K., Prozorovski, T., Meuth, S.G., Kahlert, U.D., Remke, M., Aktas, O., Reifenberger, G., Bräutigam, L., Odermatt, B., Berndt, C. (2021) Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism. Redox Biology. 49:102221
- Lin, S.J., Chiang, M.C., Shih, H.Y., Hsu, L.S., Yeh, T.H., Huang, Y.C., Lin, C.Y., Cheng, Y.C. (2017) Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade. Biochimica et biophysica acta. 1864(3):463-474
- Bui-Nguyen, T.M., Baer, C.E., Lewis, J.A., Yang, D., Lein, P.J., Jackson, D.A. (2015) Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. BMC Genomics. 16:853
- Berndt, C., Poschmann, G., Stühler, K., Holmgren, A., Bräutigam, L. (2014) Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells. Redox Biology. 2:673-8
- Bräutigam, L., Jensen, L.D., Poschmann, G., Nyström, S., Bannenberg, S., Dreij, K., Lepka, K., Prozorovski, T., Montano, S.J., Aktas, O., Uhlén, P., Stühler, K., Cao, Y., Holmgren, A., and Berndt, C. (2013) Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proceedings of the National Academy of Sciences of the United States of America. 110(50):20057-20062
- Bräutigam, L., Johansson, C., Kubsch, B., McDonough, M.A., Bill, E., Holmgren, A., and Berndt, C. (2013) An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin. Biochemical and Biophysical Research Communications. 436(3):491-496
- Bräutigam, L., Schütte, L.D., Godoy, J.R., Prozorovski, T., Gellert, M., Hauptmann, G., Holmgren, A., Lillig, C.H., and Berndt, C. (2011) Vertebrate-specific glutaredoxin is essential for brain development. Proceedings of the National Academy of Sciences of the United States of America. 108(51):20532-7
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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