Gene
cpsf1
- ID
- ZDB-GENE-040709-2
- Name
- cleavage and polyadenylation specific factor 1
- Symbol
- cpsf1 Nomenclature History
- Previous Names
-
- wu:fb24c01
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have NAD+ ADP-ribosyltransferase activity and RNA binding activity. Involved in definitive hemopoiesis; mRNA polyadenylation; and retinal ganglion cell axon guidance. Predicted to localize to mRNA cleavage and polyadenylation specificity factor complex. Human ortholog(s) of this gene implicated in myopia. Is expressed in brain; gut; head; and pectoral fin. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6894052 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Myopia 27 | 618827 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004871 | Cleavage/polyadenylation specificity factor, A subunit, C-terminal |
| Domain | IPR018846 | Cleavage/polyadenylation specificity factor, A subunit, N-terminal |
| Family | IPR050358 | RSE1/DDB1/CFT1/CPSF1 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Domain Details Per Protein
| Protein | Length | Cleavage/polyadenylation specificity factor, A subunit, C-terminal | Cleavage/polyadenylation specificity factor, A subunit, N-terminal | RSE1/DDB1/CFT1/CPSF1 | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1NHR0
|
1449 | ||||
|
UniProtKB:F6NXE7
|
1448 |
Interactions and Pathways
No data available
Plasmids
No data available