Gene
elavl2
- ID
- ZDB-GENE-040704-9
- Name
- ELAV like neuron-specific RNA binding protein 2
- Symbol
- elavl2 Nomenclature History
- Previous Names
-
- zgc:91918 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables mRNA 3'-UTR binding activity. Predicted to be part of ribonucleoprotein complex. Is expressed in central nervous system; head; ovary; and primordial germ cell. Orthologous to human ELAVL2 (ELAV like RNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91918 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022373Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-elavl2 | N/A | Mickoleit et al., 2011 |
| MO2-elavl2 | N/A | Mickoleit et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Family | IPR002343 | Paraneoplastic encephalomyelitis antigen |
| Family | IPR006548 | Splicing factor ELAV/Hu |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | Paraneoplastic encephalomyelitis antigen | RNA-binding domain superfamily | RNA recognition motif domain | Splicing factor ELAV/Hu |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6GQM6 | InterPro | 360 | |||||
| UniProtKB:A0A2R8S0A2 | InterPro | 389 | |||||
| UniProtKB:A0AB32TCI3 | InterPro | 388 | |||||
| UniProtKB:A0AB32TCW2 | InterPro | 387 | |||||
| UniProtKB:A0AB32TG59 | InterPro | 359 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
elavl2-201
(1)
|
Ensembl | 1,691 nt | ||
| mRNA |
elavl2-202
(1)
|
Ensembl | 522 nt | ||
| mRNA |
elavl2-203
(1)
|
Ensembl | 1,689 nt | ||
| mRNA |
elavl2-204
(1)
|
Ensembl | 2,539 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284E20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91918 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002172 (1) | 1759 nt | ||
| Genomic | GenBank:AL954145 (1) | 160871 nt | ||
| Polypeptide | UniProtKB:A0A2R8S0A2 (1) | 389 aa |
- Jamieson-Lucy, A.H., Kobayashi, M., James Aykit, Y., Elkouby, Y., Escobar-Aguirre, M., Vejnar, C., Giraldez, A., Mullins, M.C. (2022) A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb. Developmental Biology. 484:1-11
- Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Despic, V., Dejung, M., Gu, M., Krishnan, J., Zhang, J., Herzel, L., Straube, K., Gerstein, M.B., Butter, F., Neugebauer, K.M. (2017) Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome research. 27(7):1184-1194
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
- Takahashi, K., Kotani, T., Katsu, Y., Yamashita, M. (2014) Possible involvement of insulin-like growth factor 2 mRNA-binding protein 3 in zebrafish oocyte maturation as a novel cyclin B1 mRNA-binding protein that represses the translation in immature oocytes. Biochemical and Biophysical Research Communications. 448(1):22-7
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Mickoleit, M., Banisch, T.U., and Raz, E. (2011) Regulation of hub mRNA stability and translation by miR430 and the dead end protein promotes preferential expression in zebrafish primordial germ cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(3):695-703
- Wiszniak, S.E., Dredge, B.K., and Jensen, K.B. (2011) HuB (elavl2) mRNA Is Restricted to the Germ Cells by Post-Transcriptional Mechanisms including Stabilisation of the Message by DAZL. PLoS One. 6(6):e20773
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