Gene
snx7
- ID
- ZDB-GENE-040704-77
- Name
- sorting nexin 7
- Symbol
- snx7 Nomenclature History
- Previous Names
-
- zgc:92458
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables cysteine-type endopeptidase activity. Acts upstream of or within liver development and negative regulation of apoptotic process. Predicted to be active in early endosome and phagophore assembly site. Is expressed in gut and liver. Orthologous to human SNX7 (sorting nexin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Xu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Xu et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-snx7 | N/A | Xu et al., 2012 |
| MO2-snx7 | N/A | Xu et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | Phox homology | PX domain superfamily | SNX7, BAR domain | SNX7, PX domain | Sorting nexin/Vps5-like, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6GMJ0 | InterPro | 413 | ||||||
| UniProtKB:A0A0R4IBS8 | InterPro | 469 | ||||||
| UniProtKB:A0A0R4IIY5 | InterPro | 435 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-358J7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92458 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002229 (1) | 2246 nt | ||
| Genomic | GenBank:CU929325 (2) | 102787 nt | ||
| Polypeptide | UniProtKB:A0A0R4IBS8 (1) | 469 aa |
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Wilkins, B.J., and Pack, M. (2013) Zebrafish models of human liver development and disease. Comprehensive Physiology. 3(3):1213-1230
- Xu, L., Yin, W., Xia, J., Peng, M., Li, S., Lin, S., Pei, A., and Shum, X. (2012) An anti-apoptotic role of SNX7 is required for liver development in zebrafish. Hepatology (Baltimore, Md.). 55(6):1985-1993
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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