Gene
litaf
- ID
- ZDB-GENE-040704-23
- Name
- lipopolysaccharide-induced TNF factor
- Symbol
- litaf Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion binding activity. Predicted to be located in cytoplasmic side of early endosome membrane and cytoplasmic side of plasma membrane. Predicted to be active in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. Is expressed in pronephric duct and pronephric duct opening. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to human LITAF (lipopolysaccharide induced TNF factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91882 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bw26 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-litaf | Turan et al., 2020 | |
| MO1-litaf | N/A | Moshal et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 1C | Alliance | Charcot-Marie-Tooth disease, type 1C | 601098 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | LITAF domain containing protein | LPS-induced tumour necrosis factor alpha factor |
|---|---|---|---|---|
| UniProtKB:A0A8M3AR44 | InterPro | 162 | ||
| UniProtKB:Q6GMG8 | InterPro | 163 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-10D19 | ZFIN Curated Data | |
| Encodes | EST | fb12g04 | ||
| Encodes | EST | ibd5018 | ||
| Encodes | cDNA | MGC:91882 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002184 (1) | 2040 nt | ||
| Genomic | GenBank:BX324229 (1) | 72241 nt | ||
| Polypeptide | UniProtKB:Q6GMG8 (1) | 163 aa |
- Godoi, F.G.A., Forner-Piquer, I., Randazzo, B., Habibi, H.R., Lo Nostro, F.L., Moreira, R.G., Carnevali, O. (2021) Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. Frontiers in endocrinology. 12:677853
- Turan, N.N., Moshal, K.S., Roder, K., Baggett, B.C., Kabakov, A.Y., Dhakal, S., Teramoto, R., Chiang, D.Y., Zhong, M., Xie, A., Lu, Y., Dudley, S.C., MacRae, C.A., Karma, A., Koren, G. (2020) The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2. The Journal of biological chemistry. 295(52):18148-18159
- Moshal, K.S., Roder, K., Kabakov, A.Y., Werdich, A.A., Chiang, D.Y., Turan, N.N., Xie, A., Kim, T.Y., Cooper, L.L., Lu, Y., Zhong, M., Li, W., Terentyev, D., Choi, B.R., Karma, A., MacRae, C.A., Koren, G. (2019) LITAF Regulates Cardiac L-type Calcium Channels by Modulating NEDD4-1 Ubiquitin Ligase. Circulation. Genomic and precision medicine. 12(9):407-420
- Falcinelli, S., Randazzo, B., Vargas Abundez, J.A., Cangiotti, G., Olivotto, I., and Carnevali, O. (2018) Kluyveromyces fragilis RNA extract supplementation promotes growth, modulates stress and inflammatory response in zebrafish. Aquaculture research. 49(4):1521-1534
- Zarantoniello, M., Bruni, L., Randazzo, B., Vargas, A., Gioacchini, G., Truzzi, C., Annibaldi, A., Riolo, P., Parisi, G., Cardinaletti, G., Tulli, F., Olivotto, I. (2018) Partial Dietary Inclusion of Hermetia illucens (Black Soldier Fly) Full-Fat Prepupae in Zebrafish Feed: Biometric, Histological, Biochemical, and Molecular Implications. Zebrafish. 15(5):519-532
- Chen, Y.S., Chen, N.N., Qin, X.W., Mi, S., He, J., Lin, Y.F., Weng, S.P., Guo, C.J., Heb, J.G. (2016) Tiger Frog Virus ORF080L Protein Interacts with LITAF and Impairs EGF-induced EGFR Degradation. Virus research. 217:133-42
- Gonçalves, A.F., Páscoa, I., Neves, J.V., Coimbra, J., Vijayan, M.M., Rodrigues, P., and Wilson, J.M. (2012) The inhibitory effect of environmental ammonia on Danio rerio LPS induced acute phase response. Developmental and comparative immunology. 36(2):279-88
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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