ZFIN is now using GRCz12tu for Genomic Data
Gene
ifng1
- ID
- ZDB-GENE-040629-1
- Name
- interferon gamma 1
- Symbol
- ifng1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity and type II interferon receptor binding activity. Acts upstream of or within several processes, including defense response to bacterium; endothelial to hematopoietic transition; and response to virus. Predicted to be located in extracellular space. Is expressed in several structures, including axial vasculature; blood; digestive system; pleuroperitoneal region; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; allergic rhinitis; ataxia telangiectasia; leukemia (multiple); and liver disease (multiple). Orthologous to human IFNG (interferon gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 62 figures from 41 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu773 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aplastic anemia | Alliance | {Aplastic anemia} | 609135 |
| immunodeficiency 69 | Alliance | ?Immunodeficiency 69, mycobacteriosis | 618963 |
| tuberous sclerosis 2 | Alliance | {TSC2 angiomyolipomas, renal, modifier of} | 613254 |
| {AIDS, rapid progression to} | 609423 | ||
| {Hepatitis C virus, response to therapy of} | 609532 | ||
| {Tuberculosis, protection against} | 607948 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interferon gamma |
|---|---|---|---|---|
| UniProtKB:Q75S22 | InterPro | 185 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ifng1-2 | monoclonal |
|
1 |
Plasmids
No data available
- Genome Browsers