ZFIN ID: ZDB-GENE-040629-1
Gene Name: interferon gamma 1
Gene Symbol: ifng1    Nomenclature History

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Previous Names: ifng1-2, Ifng2 (1), ifng, Ifngamma2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have interferon-gamma receptor binding activity. Involved in several processes, including defense response to bacterium; endothelial to hematopoietic transition; and response to virus. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; ataxia telangiectasia; autoimmune hypersensitivity disease (multiple); bone disease (multiple); and leukemia (multiple). Is expressed in axial vasculature; blood; liver; and pleuroperitoneal region. Orthologous to human IFNG (interferon gamma).
Genome Resources: Alliance (1),  Gene:405790 (1),  Ensembl(GRCz11):ENSDARG00000024211 (1)
GENE EXPRESSION
All Expression Data: 41 figures from 28 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu773]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ifng1
1
CRISPR2-ifng1
1
CRISPR3-ifng1
1
MO1-ifng1 N/A 5
DISEASE ASSOCIATED WITH ifng1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aplastic anemia Alliance {Aplastic anemia} 609135
tuberous sclerosis 2 Alliance {TSC2 angiomyolipomas, renal, modifier of} 613254
{AIDS, rapid progression to} 609423
{Hepatitis C virus, response to therapy of} 609532
{Tuberculosis, protection against} 607948
DISEASE ASSOCIATED WITH ifng1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process defense response to bacterium (more)
Cellular Component extracellular region (more)
Molecular Function interferon-gamma receptor binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR002069 Interferon gamma
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ifng1-201 (1)    Ensembl 570
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-ifng1-2 monoclonal WB 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ifng1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hsp70l:ifng1-2-V5,cryaa:Cerulean) cryaahsp70l Ceruleanifng1V5 Danio rerio 1 2
MARKER RELATIONSHIPS
ifng1 Contained in: [BAC] CH211-266A5 (1)
ifng1 Encodes: [EST] eu773 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212864 (1) 570 nt
Genomic GenBank:BX465210 (1) 171708 nt
Select Tool
Polypeptide UniProtKB:Q75S22 (1) 185 aa
Sequence Information (all 12)
ORTHOLOGY for ifng1 ( Chr: 4 )
CITATIONS (134)