Gene
cyp2aa4
- ID
- ZDB-GENE-040625-72
- Name
- cytochrome P450, family 2, subfamily AA, polypeptide 4
- Symbol
- cyp2aa4 Nomenclature History
- Previous Names
-
- zgc:86915
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in integument and liver.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 family 2 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IQ77 | InterPro | 440 | |||||
| UniProtKB:A0A8M3AYT4 | InterPro | 338 | |||||
| UniProtKB:A0A8M6YV80 | InterPro | 505 | |||||
| UniProtKB:A0A8M1N004 | InterPro | 499 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp2aa4-201
(1)
|
Ensembl | 1,841 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-73D17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86915 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002092 (1) | 1844 nt | ||
| Genomic | GenBank:CU013526 (1) | 111595 nt | ||
| Polypeptide | UniProtKB:A0A8M6YV80 (1) | 505 aa |
No data available
- Shi, X.C., Sun, J., Jin, A., Ji, H., Yu, H.B., Li, Y., Li, X.X., Liu, P., Li, C., Huang, J.Q. (2018) Cytochrome P450 2AA molecular clone, expression pattern, and different regulation by fish oil and lard oil in diets of grass carp (Ctenopharyngodon idella). Fish physiology and biochemistry. 44(4):1019-1026
- Meier, M., Grant, J., Dowdle, A., Thomas, A., Gerton, J., Collas, P., O'Sullivan, J.M., Horsfield, J.A. (2017) Cohesin facilitates zygotic genome activation in zebrafish. Development (Cambridge, England). 145(1)
- Puthumana, J., Kim, B.M., Jeong, C.B., Kim, D.H., Kang, H.M., Jung, J.H., Kim, I.C., Hwang, U.K., Lee, J.S. (2017) Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP. Aquatic toxicology (Amsterdam, Netherlands). 187:132-140
- Chai, T., Cui, F., Mu, P., Yang, Y., Xu, N., Yin, Z., Jia, Q., Yang, S., Qiu, J., Wang, C. (2016) Enantio-alteration of gene transcription associated with bioconcentration in adult zebrafish (Danio rerio) exposed to chiral PCB149. Scientific Reports. 6:19478
- Chai, T., Cui, F., Mu, X., Yang, Y., Wang, C., Qiu, J. (2016) Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels. PLoS One. 11:e0155263
- Li, Z., Long, Y., Zhong, L., Song, G., Zhang, X., Yuan, L., Cui, Z., Dai, H. (2016) RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate. Journal of applied toxicology : JAT. 36(1):94-104
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kubota, A., Bainy, A.C., Woodin, B.R., Goldstone, J.V., and Stegeman, J.J. (2013) The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): Expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and applied pharmacology. 272(1):172-9
- Tao, T., Shi, H., Huang, D., and Peng, J. (2013) Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. PLoS One. 8(4):e58858
- Kirischian, N., McArthur, A.G., Jesuthasan, C., Krattenmacher, B., and Wilson, J.Y. (2011) Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family. Journal of molecular evolution. 72(1):56-71
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