Gene
rac2
- ID
- ZDB-GENE-040625-27
- Name
- Rac family small GTPase 2
- Symbol
- rac2 Nomenclature History
- Previous Names
-
- zgc:86686
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including defense response to other organism; leukocyte chemotaxis; and regulation of neutrophil migration. Localizes to cytoplasm. Is expressed in neutrophil and thymus. Orthologous to human RAC2 (Rac family small GTPase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6895520 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis | Alliance | Immunodeficiency 73A with defective neutrophil chemotaxix and leukocytosis | 608203 |
| immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia | Alliance | Immunodeficiency 73B with defective neutrophil chemotaxis and lymphopenia | 618986 |
| immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia | Alliance | ?Immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia | 618987 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:Q6IQN5
|
192 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-rac2 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids