Gene
rac2
- ID
- ZDB-GENE-040625-27
- Name
- Rac family small GTPase 2
- Symbol
- rac2 Nomenclature History
- Previous Names
-
- zgc:86686
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within several processes, including defense response to other organism; leukocyte chemotaxis; and regulation of neutrophil migration. Located in cytoplasm. Is expressed in blood island; caudal hematopoietic tissue; neutrophil; rostral blood island; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6895520 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ioz108 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| sa31335 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uwm29 | Allele with one delins | Exon 3 | Frameshift, Premature Stop | TALEN | |
| uwm30 | Allele with one delins | Exon 3 | Frameshift, Premature Stop | TALEN | |
| uwm31 | Allele with one deletion | Exon 5 | Frameshift, Premature Stop | TALEN | |
| uwm32 | Allele with one deletion | Exon 5 | Frameshift, Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rac2 | (2) | |
| CRISPR2-rac2 | (2) | |
| CRISPR3-rac2 | Lu et al., 2020 | |
| MO1-rac2 | N/A | (6) |
| MO2-rac2 | N/A | Lu et al., 2020 |
| TALEN1-rac2 | Rosowski et al., 2016 | |
| TALEN2-rac2 | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis | Alliance | Immunodeficiency 73A with defective neutrophil chemotaxix and leukocytosis | 608203 |
| immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia | Alliance | Immunodeficiency 73B with defective neutrophil chemotaxis and lymphopenia | 618986 |
| immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia | Alliance | ?Immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia | 618987 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6IQN5 | InterPro | 192 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-rac2 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lyz:mCherry-2A-rac2) |
| 1 | Wang et al., 2021 | ||
| Tg(lyz:mCherry-2A-rac2_Q61L) |
| 1 | Wang et al., 2021 | ||
| Tg(mpeg1.1:mCherry-2A-rac2) |
| 1 | (3) | ||
| Tg(mpx:mCherry,rac2) |
|
| 1 | (14) | |
| Tg(mpx:mCherry,rac2_D57N) |
|
| 1 | (29) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-165I8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6895520 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86686 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002061 (1) | 1231 nt | ||
| Genomic | GenBank:BX571960 (2) | 192501 nt | ||
| Polypeptide | UniProtKB:Q6IQN5 (1) | 192 aa |
- Tanner, C.D., Rosowski, E.E. (2024) Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling. Infection and Immunity. 92(2):e0038023
- Thrikawala, S.U., Anderson, M.H., Rosowski, E.E. (2024) Glucocorticoids Suppress NF-κB-Mediated Neutrophil Control of Aspergillus fumigatus Hyphal Growth. Journal of immunology (Baltimore, Md. : 1950). 213(7):971-987
- Schoen, T.J., Calise, D.G., Bok, J.W., Giese, M.A., Nwagwu, C.D., Zarnowski, R., Andes, D., Huttenlocher, A., Keller, N.P. (2023) Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection. PLoS pathogens. 19:e1011152e1011152
- Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149
- Horton, M.V., Johnson, C.J., Zarnowski, R., Andes, B.D., Schoen, T.J., Kernien, J.F., Lowman, D., Kruppa, M.D., Ma, Z., Williams, D.L., Huttenlocher, A., Nett, J.E. (2021) Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata. mSphere. 6(3):e0040621
- Houseright, R.A., Miskolci, V., Mulvaney, O., Bortnov, V., Mosher, D.F., Rindy, J., Bennin, D.A., Huttenlocher, A. (2021) Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage. The Journal of cell biology. 220(8):
- Wang, Y., Hsu, A.Y., Walton, E.M., Park, S.J., Syahirah, R., Wang, T., Zhou, W., Ding, C., Lemke, A.P., Zhang, G., Tobin, D.M., Deng, Q. (2021) A robust and flexible CRISPR/Cas9 based system for neutrophil-specific gene inactivation in zebrafish. Journal of Cell Science. 134(8):
- Barros-Becker, F., Squirrell, J.M., Burke, R., Chini, J., Rindy, J., Karim, A., Eliceiri, K.W., Gibson, A., Huttenlocher, A. (2020) Distinct Tissue Damage and Microbial Cues Drive Neutrophil and Macrophage Recruitment to Thermal Injury. iScience. 23:101699
- Bastos, R.W., Valero, C., Silva, L.P., Schoen, T., Drott, M., Brauer, V., Silva-Rocha, R., Lind, A., Steenwyk, J.L., Rokas, A., Rodrigues, F., Resendiz-Sharpe, A., Lagrou, K., Marcet-Houben, M., Gabaldón, T., McDonnell, E., Reid, I., Tsang, A., Oakley, B.R., Loures, F.V., Almeida, F., Huttenlocher, A., Keller, N.P., Ries, L.N.A., Goldman, G.H. (2020) Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere. 5(2):
- Blachowicz, A., Raffa, N., Bok, J.W., Choera, T., Knox, B., Lim, F.Y., Huttenlocher, A., Wang, C.C.C., Venkateswaran, K., Keller, N.P. (2020) Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. mBio. 11(1):
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