Gene
eif2b1
- ID
- ZDB-GENE-040625-25
- Name
- eukaryotic translation initiation factor 2B, subunit 1 alpha
- Symbol
- eif2b1 Nomenclature History
- Previous Names
-
- zgc:86660
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in regulation of translational initiation and translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6894278 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 1 | Alliance | Leukoencephalopathy with vanishing white matter 1, with or without ovarian failure | 603896 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Initiation factor 2B-like, C-terminal | Initiation factor 2B-related | NagB/RpiA transferase-like | Translation initiation factor eIF-2B subunit alpha, N-terminal |
|---|---|---|---|---|---|
|
UniProtKB:A0A0R4ILD9
|
302 | ||||
|
UniProtKB:Q6IQQ8
|
291 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
eif2b1-201
(1)
|
Havana | 1218 nt |
Interactions and Pathways
No data available
Plasmids
No data available