ZFIN is now using GRCz12tu for Genomic Data
Gene
lum
- ID
- ZDB-GENE-040625-24
- Name
- lumican
- Symbol
- lum Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within collagen fibril organization and embryonic camera-type eye morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; epidermis; head mesenchyme; heart; and nervous system. Used to study myopia. Human ortholog(s) of this gene implicated in carotid artery disease; coronary artery disease; and pancreatic cancer. Orthologous to human LUM (lumican).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145913 (1 image)
- IMAGE:6904895 (23 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myopia | AB/TU + MO1-lum | standard conditions | Lin et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Small Leucine-Rich Proteoglycans |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IQQ7 | InterPro | 344 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers