Gene
eaf2
- ID
- ZDB-GENE-040625-179
- Name
- ELL associated factor 2
- Symbol
- eaf2 Nomenclature History
- Previous Names
-
- wu:fb76c01
- wu:fc43g12
- zgc:86600
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables armadillo repeat domain binding activity; beta-catenin binding activity; and transcription corepressor activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; convergent extension; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including blastoderm; blastodisc; nervous system; pleuroperitoneal region; and presumptive neural retina. Orthologous to human EAF2 (ELL associated factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6892795 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EAF family | Transcription elongation factor Eaf, N-terminal |
|---|---|---|---|---|
| UniProtKB:Q6IQU8 | InterPro | 259 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-91I10 | ZFIN Curated Data | |
| Contains | SNP | rs3728225 | ZFIN Curated Data | |
| Encodes | EST | fb76c01 | ||
| Encodes | EST | fc43g12 | ||
| Encodes | EST | IMAGE:6892795 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86600 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002162 (1) | 1985 nt | ||
| Genomic | GenBank:CR394542 (1) | 193811 nt | ||
| Polypeptide | UniProtKB:Q6IQU8 (1) | 259 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Liu, J.X., Xu, Q.H., Yu, X., Zhang, T., Xie, X., Ouyang, G. (2018) Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/β-Catenin activity.. International journal of biological sciences. 14:705-716
- Liu, J.X., Xu, Q.H., Li, S., Yu, X., Liu, W., Ouyang, G., Zhang, T., Chen, L.L. (2017) Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-β signaling. Biochimica et biophysica acta. 1860(10):1103-1116
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, J.X., Zhang, D., Xie, X., Ouyang, G., Liu, X., Sun, Y., and Xiao, W. (2013) Eaf1 and Eaf2 negatively regulate canonical Wnt/β-catenin signaling. Development (Cambridge, England). 140(5):1067-1078
- Wan, X., Ji, W., Mei, X., Zhou, J., Liu, J.X., Fang, C., and Xiao, W. (2010) Negative Feedback Regulation of Wnt4 Signaling by EAF1 and EAF2/U19. PLoS One. 5(2):e9118
- Liu, J.X., Hu, B., Wang, Y., Gui, J.F., and Xiao, W. (2009) Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. The Journal of biological chemistry. 284(24):16679-16692
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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