Gene

dguok

ID

ZDB-GENE-040625-14

Name

deoxyguanosine kinase

Symbol

dguok Nomenclature History

Previous Names

zgc:86625

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable deoxyguanosine kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; mitochondrial metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6892866 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dguok Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4	Alliance	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4	617070
mitochondrial DNA depletion syndrome 3	Alliance	Mitochondrial DNA depletion syndrome 3 (hepatocerebral type)	251880
		Portal hypertension, noncirrhotic, 1	617068

Associated With dguok Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR031314	Deoxynucleoside kinase domain
Family	IPR002624	Deoxynucleoside kinase
Family	IPR050566	Deoxyribonucleoside Kinase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase