Gene
guk1a
- ID
- ZDB-GENE-040625-130
- Name
- guanylate kinase 1a
- Symbol
- guk1a Nomenclature History
- Previous Names
-
- sb:cb295
- zgc:86776
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable guanylate kinase activity. Predicted to act upstream of or within phosphorylation and purine nucleotide metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in cardiovascular system; neural tube; polster; spinal cord; and yolk syncytial layer. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome-21. Orthologous to human GUK1 (guanylate kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb295 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome-21 | Alliance | Mitochondrial DNA depletion syndrome 21 | 621071 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Family | IPR017665 | Guanylate kinase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QGR9 | InterPro | 208 | |||||
| UniProtKB:A0A2R8RJH6 | InterPro | 211 | |||||
| UniProtKB:Q6IQG1 | InterPro | 199 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available