Gene
tnni2a.4
- ID
- ZDB-GENE-040625-119
- Name
- troponin I type 2a (skeletal, fast), tandem duplicate 4
- Symbol
- tnni2a.4 Nomenclature History
- Previous Names
-
- tnni2
- TnnI2
- tropI-1d (1)
- hm:zehn0173
- zgc:86800
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Involved in myofibril assembly. Predicted to localize to troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B1 and intrinsic cardiomyopathy (multiple). Is expressed in musculature system and somite. Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907617 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 2B1 | Alliance | Arthrogryposis, distal, type 2B1 | 601680 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Troponin | Troponin domain superfamily | Troponin I |
|---|---|---|---|---|
|
UniProtKB:A0A8M2BA47
|
178 | |||
|
UniProtKB:Q0D2W2
|
176 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnni2a.4-201
(1)
|
Ensembl | 764 nt | ||
| mRNA |
tnni2a.4-202
(1)
|
Ensembl | 1,331 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- tnni2a.1, tnni2a.2, tnni2a.3, and tnni2a.4 form a cluster on chromosome 25 and are likely the result of tandem duplications. The location of the cluster in zebrafish as well as the amino acid identity of all genes in the cluster support orthology to human TNNI2 and mouse Tnni2.