Gene

adgrv1

ID

ZDB-GENE-040624-6

Name

adhesion G protein-coupled receptor V1

Symbol

adgrv1 Nomenclature History

Previous Names

vlgr1 (1)
gpr98
mass1 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and adenylate cyclase inhibitor activity. Acts upstream of or within eye photoreceptor cell development and visual perception. Predicted to be located in photoreceptor inner segment and stereocilium membrane. Predicted to be active in cytoplasm and stereocilium. Is expressed in integument; nervous system; and pleuroperitoneal region. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7139473 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Stemerdink et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adgrv1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial febrile seizures 4	Alliance	?Febrile seizures, familial, 4	604352
Usher syndrome type 2C	Alliance	Usher syndrome, type 2C	605472
Usher syndrome type 2C	Alliance	Usher syndrome, type 2C, GPR98/PDZD7 digenic	605472

Associated With adgrv1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
retinitis pigmentosa	adgrv1^rmc22/rmc22 (AB)	standard conditions	Stemerdink et al., 2023

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Domain	IPR003609	PAN/Apple domain
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Domain	IPR006558	LamG-like jellyroll fold
Domain	IPR017981	GPCR, family 2-like, 7TM
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR026919	Adhesion G-protein coupled receptor V1
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily
Repeat	IPR009039	EAR