Gene
rgma
- ID
- ZDB-GENE-040527-1
- Name
- repulsive guidance molecule BMP co-receptor a
- Symbol
- rgma Nomenclature History
- Previous Names
-
- id:ibd2030
- wu:fb72h09
- zgc:110534 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable coreceptor activity. Acts upstream of with a positive effect on membrane protein intracellular domain proteolysis. Acts upstream of or within cell morphogenesis. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; hindbrain neural plate; hindbrain neural rod; notochord; and tail bud. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rgma | Brown et al., 2019 | |
| CRISPR2-rgma | Brown et al., 2019 | |
| MO1-rgma | N/A | (2) |
| MO2-rgma | N/A | Brown et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Repulsive guidance molecule | Repulsive guidance molecule, C-terminal | Repulsive guidance molecule, N-terminal |
|---|---|---|---|---|---|
| UniProtKB:Q1LVM8 | InterPro | 449 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196L7 | ZFIN Curated Data | |
| Encodes | EST | fb72h09 | ZFIN Curated Data | |
| Encodes | EST | ibd2030 | ||
| Encodes | EST | IMAGE:7140541 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110534 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192952 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045011 (1) | 4366 nt | ||
| Genomic | GenBank:BX649578 (1) | 211922 nt | ||
| Polypeptide | UniProtKB:Q1LVM8 (1) | 449 aa |
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Espino-Saldaña, A.E., Durán-Ríos, K., Olivares-Hernandez, E., Rodríguez-Ortiz, R., Arellano-Carbajal, F., Martínez-Torres, A. (2020) Temporal and spatial expression of zebrafish mctp genes and evaluation of frameshift alleles of mctp2b. Gene. 738:144371
- Brown, S., Jayachandran, P., Negesse, M., Olmo, V., Vital, E., Brewster, R. (2019) Rgma-induced Neo1 proteolysis promotes neural tube morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(38):7465-7484
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, C.C., Kruse, F., Vasudevarao, M.D., Junker, J.P., Zebrowski, D.C., Fischer, K., Noël, E.S., Grün, D., Berezikov, E., Engel, F.B., van Oudenaarden, A., Weidinger, G., Bakkers, J. (2016) Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration. Developmental Cell. 36(1):36-49
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gao, X., Metzger, U., Panza, P., Mahalwar, P., Alsheimer, S., Geiger, H., Maischein, H.M., Levesque, M.P., Templin, M., Söllner, C. (2015) A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Cell Reports. 12(4):694-708
- Gibert, Y., Lattanzi, V.J., Zhen, A.W., Vedder, L., Brunet, F., Faasse, S.A., Babitt, J.L., Lin, H.Y., Hammerschmidt, M., and Fraenkel, P.G. (2011) BMP Signaling Modulates Hepcidin Expression in Zebrafish Embryos Independent of Hemojuvelin. PLoS One. 6(1):e14553
- Cañestro, C., Catchen, J.M., Rodriguez-Mari, A., Yokoi, H., and Postlethwait, J.H. (2009) Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. PLoS Genetics. 5(5):e1000496
- Camus, L.M., and Lambert, L.A. (2007) Molecular evolution of hemojuvelin and the repulsive guidance molecule family. Journal of molecular evolution. 65(1):68-81
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