Gene
arhgef18a
- ID
- ZDB-GENE-040516-14
- Name
- rho/rac guanine nucleotide exchange factor (GEF) 18a
- Symbol
- arhgef18a Nomenclature History
- Previous Names
-
- arhgef18
- wu:fc21e04
- wu:fj05f11
- zgc:85686
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Retinitis pigmentosa 78 | 617433 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ARHGEF1-like, PH domain | Dbl homology (DH) domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Rho guanine nucleotide exchange factor |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6NSP2
|
940 | |||||
|
UniProtKB:A0A8M3AXD6
|
940 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef18a-201
(1)
|
Ensembl | 4,184 nt | ||
| mRNA |
arhgef18a-202
(1)
|
Ensembl | 389 nt | ||
| mRNA |
arhgef18a-203
(1)
|
Ensembl | 554 nt |
Interactions and Pathways
No data available
Plasmids
No data available