Gene
tcf12
- ID
- ZDB-GENE-040516-11
- Name
- transcription factor 12
- Symbol
- tcf12 Nomenclature History
- Previous Names
-
- TF12 (1)
- wu:fb74g05
- wu:fc43e06
- zgc:110341
- zgc:85956
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within camera-type eye development and neuron projection development. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Is expressed in several structures, including cranial vault; mesoderm; nervous system; neural tube; and presumptive diencephalon. Human ortholog(s) of this gene implicated in craniosynostosis 3 and hypogonadotropic hypogonadism. Orthologous to human TCF12 (transcription factor 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110341 (14 images)
- eu268 (19 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| el548 | Allele with one delins | Unknown | Unknown | TALEN | |
| la011008Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026141Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026142Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14175 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27060 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31600 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45298 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tcf12 | Davis et al., 2020 | |
| CRISPR2-tcf12 | Buono et al., 2021 | |
| CRISPR3-tcf12 | Buono et al., 2021 | |
| MO1-tcf12 | N/A | Davis et al., 2020 |
| MO2-tcf12 | N/A | Davis et al., 2020 |
| TALEN1-tcf12 | Teng et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniosynostosis 3 | Alliance | Craniosynostosis 3 | 615314 |
| Hypogonadotropic hypogonadism 26 with or without anosmia | 619718 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neuronal Differentiation E-box Binding Transcription Factors |
|---|---|---|---|---|---|
| UniProtKB:A0A0R4IBL7 | InterPro | 726 | |||
| UniProtKB:A0A8M2BDZ2 | InterPro | 696 | |||
| UniProtKB:A0A1L1QZH9 | InterPro | 713 | |||
| UniProtKB:A0A1L1QZA0 | InterPro | 689 | |||
| UniProtKB:A0A1L1QZF4 | InterPro | 557 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.2tcf12:EGFP) |
|
| 1 | Blümel et al., 2019 | |
| Tg(-2.1tcf12:EGFP) |
|
| 1 | Blümel et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-258F15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-175I15 | ZFIN Curated Data | |
| Encodes | EST | eu268 | Thisse et al., 2005 | |
| Encodes | EST | fb74g05 | ZFIN Curated Data | |
| Encodes | EST | fc43e06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85956 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110341 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214816 (1) | 4265 nt | ||
| Genomic | GenBank:BX323544 (2) | 182033 nt | ||
| Polypeptide | UniProtKB:A0A0R4IBL7 (1) | 726 aa |
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Davis, E.E., Balasubramanian, R., Kupchinsky, Z.A., Keefe, D.L., Plummer, L., Khan, K., Meczekalski, B., Heath, K.E., Lopez-Gonzalez, V., Ballesta-Martinez, M.J., Margabanthu, G., Price, S., Greening, J., Brauner, R., Valenzuela, I., Cusco, I., Fernandez-Alvarez, P., Wierman, M.E., Li, T., Lage, K., Barroso, P.S., Chan, Y.M., Crowley, W.F., Katsanis, N. (2020) TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Human molecular genetics. 29(14):2435-2450
- Blümel, R., Zink, M., Klopocki, E., Liedtke, D. (2019) On the traces of tcf12: Investigation of the gene expression pattern during development and cranial suture patterning in zebrafish (Danio rerio). PLoS One. 14:e0218286
- Teng, C.S., Ting, M.C., Farmer, D.T., Brockop, M., Maxson, R.E., Crump, J.G. (2018) Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome. eLIFE. 7:
- Payumo, A.Y., McQuade, L.E., Walker, W.J., Yamazoe, S., Chen, J.K. (2016) Tbx16 regulates hox gene activation in mesodermal progenitor cells. Nature Chemical Biology. 12(9):694-701
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Rösel, T.D., Hung, L.H., Medenbach, J., Donde, K., Starke, S., Benes, V., Rätsch, G., and Bindereif, A. (2011) RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. The EMBO journal. 30(10):1965-1976
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