Gene

tcf12

ID

ZDB-GENE-040516-11

Name

transcription factor 12

Symbol

tcf12 Nomenclature History

Previous Names

TF12 (1)
wu:fb74g05
wu:fc43e06
zgc:110341
zgc:85956

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have several functions, including DNA-binding transcription factor activity; bHLH transcription factor binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in craniosynostosis. Is expressed in several structures, including central nervous system; cranial vault; mesoderm; neural tube; and presumptive diencephalon. Orthologous to human TCF12 (transcription factor 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110341 (14 images)
eu268 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf12 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
craniosynostosis	Alliance	Craniosynostosis 3	615314
		Hypogonadotropic hypogonadism 26 with or without anosmia	619718

Associated With tcf12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR051098	Neuronal Differentiation E-box Binding Transcription Factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	Myc-type, basic helix-loop-helix (bHLH) domain	Neuronal Differentiation E-box Binding Transcription Factors
UniProtKB:A0A0R4IBL7 InterPro	726
UniProtKB:A0A8M2BDZ2 InterPro	696
UniProtKB:A0A1L1QZH9 InterPro	713
UniProtKB:A0A1L1QZA0 InterPro	689
UniProtKB:A0A1L1QZF4 InterPro	557
UniProtKB:A0A8M3BB85 InterPro	702
UniProtKB:A0A8M3B1F3 InterPro	726
UniProtKB:A0A1L1QZR8 InterPro	551
UniProtKB:A0A8M3AUH5 InterPro	702
UniProtKB:A0A9B0A4S3 InterPro	533
UniProtKB:A0A8M3AUI8 InterPro	720

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tcf12-201 (1) Ensembl	Havana	4276 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-202 (1) Ensembl	Ensembl	1817 nt	Select Tool ZFIN BLAST
mRNA	tcf12-203 (1) Ensembl	Havana	2291 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-204 (1) Ensembl	Havana	513 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-205 (1) Ensembl	Havana	1099 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-207 (1) Ensembl	Havana	4982 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-209 (1) Ensembl	Havana	4875 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-210 (1) Ensembl	Havana	4447 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-211 (1) Ensembl	Havana	4429 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-212 (1) Ensembl	Havana	4431 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-213 (1) Ensembl	Havana	4947 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf12-214 (1) Ensembl	Havana	749 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tcf12-004 (1) Ensembl	Havana	839 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tcf12-009 (1) Ensembl	Havana	1184 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations