Gene
ela2l
- ID
- ZDB-GENE-040511-1
- Name
- elastase 2 like
- Symbol
- ela2l Nomenclature History
- Previous Names
-
- elastaseB (1)
- fi40a05
- wu:fi40a05
- zgc:111871
- zgc:63744
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Is expressed in exocrine pancreas; liver; and pancreas. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 4. Orthologous to human CELA2A (chymotrypsin like elastase 2A) and CELA2B (chymotrypsin like elastase 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63744 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR050850 | Peptidase S1 family, Elastase subfamily |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Peptidase S1A, chymotrypsin family | Peptidase S1 family, Elastase subfamily | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SZ51 | InterPro | 267 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24F17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-163F12 | ZFIN Curated Data | |
| Encodes | EST | fi40a05 | ||
| Encodes | cDNA | MGC:63744 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111871 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113933 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199886 (1) | 881 nt | ||
| Genomic | GenBank:BX784023 (1) | 231254 nt | ||
| Polypeptide | UniProtKB:Q7SZ51 (1) | 267 aa |
No data available
- Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Shui, G., Sun, Y. (2024) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nature communications. 15:97699769
- Zhang, Z., Yang, C., Wang, Z., Guo, L., Xu, Y., Gao, C., Sun, Y., Zhang, Z., Peng, J., Hu, M., Jan Lo, L., Ma, Z., Chen, J. (2023) Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis. Cell death discovery. 9:227227
- Bordeira-Carriço, R., Teixeira, J., Duque, M., Galhardo, M., Ribeiro, D., Acemel, R.D., Firbas, P.N., Tena, J.J., Eufrásio, A., Marques, J., Ferreira, F.J., Freitas, T., Carneiro, F., Goméz-Skarmeta, J.L., Bessa, J. (2022) Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nature communications. 13:1945
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Schwepe, C.W., Wojno, M., Molinari, G.S., Kwasek, K. (2022) The Effects of Plant Protein-Enriched Live Food on Larval Zebrafish Growth and the Status of Its Digestive Tract Development. Zebrafish. 19(6):229-240
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Yoon, B., Yeung, P., Santistevan, N., Bluhm, L., Kawasaki, K., Kueper, J., Dubielzig, R., Vanoudenhove, J., Cotney, J., Liao, E.C., Grinblat, Y. (2022) Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye. Biology Open. 11(5):
- Huang, Y., Huang, C.X., Wang, W.F., Liu, H., Wang, H.L. (2020) Zebrafish miR-462-731 is required for digestive organ development. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 34:100679
- Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
- Huang, V., Butler, A.A., Lubin, F.D. (2019) Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Scientific Reports. 9:1379
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