Gene
ercc2
- ID
- ZDB-GENE-040426-997
- Name
- excision repair cross-complementation group 2
- Symbol
- ercc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable DNA helicase activity and damaged DNA binding activity. Acts upstream of or within endodermal digestive tract morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; female organism; gonad; male organism; and precaudal vertebra. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Ma et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebrooculofacioskeletal syndrome 2 | Alliance | ?Cerebrooculofacioskeletal syndrome 2 | 610756 |
| photosensitive trichothiodystrophy 1 | Alliance | Trichothiodystrophy 1, photosensitive | 601675 |
| xeroderma pigmentosum group D | Alliance | Xeroderma pigmentosum, group D | 278730 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| Domain | IPR006554 | Helicase-like, DEXD box c2 type |
| Domain | IPR006555 | ATP-dependent helicase, C-terminal |
| Domain | IPR010614 | RAD3-like helicase, DEAD |
| Domain | IPR010643 | Helical and beta-bridge domain |
| Domain | IPR014013 | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type |
| Family | IPR001945 | RAD3/XPD |
| Family | IPR013020 | ATP-dependent helicase Rad3/Chl1-like |
| Family | IPR045028 | Helicase superfamily 1/2, DinG/Rad3-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent helicase, C-terminal | ATP-dependent helicase Rad3/Chl1-like | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | Helical and beta-bridge domain | Helicase-like, DEXD box c2 type | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | Helicase superfamily 1/2, DinG/Rad3-like | P-loop containing nucleoside triphosphate hydrolase | RAD3-like helicase, DEAD | RAD3/XPD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q5E7 | InterPro | 760 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31M14 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6910620 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56365 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200926 (1) | 2581 nt | ||
| Genomic | GenBank:CR855332 (1) | 212455 nt | ||
| Polypeptide | UniProtKB:F1Q5E7 (1) | 760 aa |
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Chen, Z., Song, Z., Yang, J., Huang, J., Jiang, H. (2019) Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae. Journal of biosciences. 44(6):
- Costa, S.R., Velasques, R.R., Hoff, M.L.M., Souza, M.M., Sandrini, J.Z. (2019) Characterization of different DNA repair pathways in hepatic cells of Zebrafish (Danio rerio). DNA repair. 83:102695
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Silva, I.A., Conceição, N. (2015) Cloning, characterization and analysis of the 5' regulatory region of zebrafish xpd gene. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 185:47-53
- Šrut, M., Bourdineaud, J.P., Štambuk, A., Klobučar, G.I. (2015) Genomic and gene expression responses to genotoxic stress in PAC2 zebrafish embryonic cell line. Journal of applied toxicology : JAT. 35(11):1381-9
- Lin, C., Lin, C.N., Wang, Y.C., Liu, F.Y., Chien, Y.W., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., Chen, B.S. (2014) Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. BMC systems biology. 8 Suppl 5:S6
- Silva, I.A., Cox, C.J., Leite, R.B., Cancela, M.L., Conceição, N. (2014) Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 172-173C:9-20
- Silva, I.A., Cancela, M.L., and Conceição, N. (2012) Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). Molecular biology reports. 39(5):5339-5348
- Soares, J., Castro, L.F., Reis-Henriques, M.A., Monteiro, N.M., and Santos, M.M. (2012) Zebrafish (Danio rerio) life-cycle exposure to chronic low doses of ethinylestradiol modulates p53 gene transcription within the gonads, but not NER pathways. Ecotoxicology (London, England). 21(5):1513-1522
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