Gene
wdr45
- ID
- ZDB-GENE-040426-990
- Name
- WD repeat domain 45
- Symbol
- wdr45 Nomenclature History
- Previous Names
-
- zgc:56345 (1)
- zgc:77017
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; autophagy of nucleus; and protein localization to phagophore assembly site. Predicted to localize to cytosol; extrinsic component of membrane; and phagophore assembly site membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to human WDR45 (WD repeat domain 45).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56345 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodegeneration with brain iron accumulation 5 | Alliance | Neurodegeneration with brain iron accumulation 5 | 300894 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PROPPIN | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZUX3
|
358 | ||||
|
UniProtKB:A0A0R4I9F8
|
358 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available