Gene

rnaseh2a

ID

ZDB-GENE-040426-976

Name

ribonuclease H2, subunit A

Symbol

rnaseh2a Nomenclature History

Previous Names

zgc:56307

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to localize to ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144748 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rnaseh2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Aicardi-Goutieres syndrome	Alliance	Aicardi-Goutieres syndrome 4	610333

Associated With rnaseh2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024567	Ribonuclease HII/HIII domain
Family	IPR001352	Ribonuclease HII/HIII
Family	IPR004649	Ribonuclease H2, subunit A
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR023160	Ribonuclease HII, helix-loop-helix cap domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily

Domain Details Per Protein

Protein	Length	Ribonuclease H2, subunit A	Ribonuclease HII, helix-loop-helix cap domain superfamily	Ribonuclease HII/HIII	Ribonuclease HII/HIII domain	Ribonuclease H-like superfamily	Ribonuclease H superfamily
UniProtKB:Q6IQM9 InterPro	307

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	rnaseh2a-202 (1) Ensembl	Ensembl	787 nt	Select Tool
mRNA	rnaseh2a-201 (1) Ensembl	Ensembl	1,302 nt	Select Tool
mRNA	rnaseh2a-203 (1) Ensembl	Ensembl	1,089 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations