ZFIN is now using GRCz12tu for Genomic Data
Gene
rnaseh2a
- ID
- ZDB-GENE-040426-976
- Name
- ribonuclease H2, subunit A
- Symbol
- rnaseh2a Nomenclature History
- Previous Names
-
- zgc:56307
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to act upstream of or within RNA metabolic process. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144748 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aicardi-Goutieres syndrome | Alliance | Aicardi-Goutieres syndrome 4 | 610333 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024567 | Ribonuclease HII/HIII domain |
| Family | IPR001352 | Ribonuclease HII/HIII |
| Family | IPR004649 | Ribonuclease H2, subunit A |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR023160 | Ribonuclease HII, helix-loop-helix cap domain superfamily |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ribonuclease H2, subunit A | Ribonuclease HII, helix-loop-helix cap domain superfamily | Ribonuclease HII/HIII | Ribonuclease HII/HIII domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IQM9 | InterPro | 307 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
rnaseh2a-202
(1)
|
Ensembl | 787 nt | ||
| mRNA |
rnaseh2a-201
(1)
|
Ensembl | 1,302 nt | ||
| mRNA |
rnaseh2a-203
(1)
|
Ensembl | 1,089 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers