Gene

tnni2a.2

ID
ZDB-GENE-040426-970
Name
troponin I type 2a (skeletal, fast), tandem duplicate 2
Symbol
tnni2a.2 Nomenclature History
Previous Names
  • tropI-1b (1)
  • zgc:56294
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to localize to troponin complex. Is expressed in cephalic musculature and myotome. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B1. Orthologous to human TNNI2 (troponin I2, fast skeletal type).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnni2a.2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
distal arthrogryposis Alliance Arthrogryposis, distal, type 2B1 601680
distal arthrogryposis type 2B1 Alliance Arthrogryposis, distal, type 2B1 601680
Associated With tnni2a.2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001978 Troponin
Homologous_superfamily IPR038077 Troponin domain superfamily
Domain Details Per Protein
Protein Length Troponin Troponin domain superfamily
UniProtKB:F8W3J9 178
UniProtKB:Q7ZUR7 161
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
tnni2a.1, tnni2a.2, tnni2a.3, and tnni2a.4 form a cluster on chromosome 25 and are likely the result of tandem duplications. The location of the cluster in zebrafish as well as the amino acid identity of all genes in the cluster support orthology to human TNNI2 and mouse Tnni2.
Citations