Gene
hmgcl
- ID
- ZDB-GENE-040426-958
- Name
- 3-hydroxy-3-methylglutaryl-CoA lyase
- Symbol
- hmgcl Nomenclature History
- Previous Names
-
- zgc:56248
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process and leucine catabolic process. Predicted to be located in peroxisome. Is expressed in liver. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA lyase deficiency | Alliance | HMG-CoA lyase deficiency | 246450 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | HMG-CoA lyase | Hydroxymethylglutaryl-CoA lyase, active site | Pyruvate carboxyltransferase |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZV32
|
340 |
Interactions and Pathways
No data available
Plasmids
No data available