Gene
aacs
- ID
- ZDB-GENE-040426-903
- Name
- acetoacetyl-CoA synthetase
- Symbol
- aacs Nomenclature History
- Previous Names
-
- zgc:56105 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in liver; nervous system; neural tube; and optic vesicle. Orthologous to human AACS (acetoacetyl-CoA synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136547 (6 images)
- IMAGE:7149117 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020845 | AMP-binding, conserved site |
| Domain | IPR000873 | AMP-dependent synthetase/ligase domain |
| Domain | IPR032387 | Acetyl-coenzyme A synthetase, N-terminal domain |
| Family | IPR005914 | Acetoacetyl-CoA synthase |
| Homologous_superfamily | IPR042099 | ANL, N-terminal domain |
| Homologous_superfamily | IPR045851 | AMP-binding enzyme, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Acetoacetyl-CoA synthase | Acetyl-coenzyme A synthetase, N-terminal domain | AMP-binding, conserved site | AMP-binding enzyme, C-terminal domain superfamily | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A3QK15
|
673 |
Interactions and Pathways
No data available
Plasmids
No data available