Gene
chd1l
- ID
- ZDB-GENE-040426-892
- Name
- chromodomain helicase DNA binding protein 1-like
- Symbol
- chd1l Nomenclature History
- Previous Names
-
- zgc:56084 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP hydrolysis activity; nucleosome binding activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Acts upstream of or within brain development. Predicted to be located in chromosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human CHD1L (chromodomain helicase DNA binding protein 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pahlevan Kakhki et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8828 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9462 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14029 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18631 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26779 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | Chromodomain-helicase-DNA-binding protein 1-like | DNA ligase 3, BRCT domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | Macro domain | Macro domain-like | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU90 | InterPro | 1026 | ||||||||||||
| UniProtKB:A0AB32TSB1 | InterPro | 1026 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-29L19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-255N14 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7141250 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56084 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200313 (1) | 4389 nt | ||
| Genomic | GenBank:BX004839 (1) | 223000 nt | ||
| Polypeptide | UniProtKB:A0AB32TSB1 (1) | 1026 aa |
- Pahlevan Kakhki, M., Giordano, A., Starvaggi Cucuzza, C., Venkata S Badam, T., Samudyata, S., Lemée, M.V., Stridh, P., Gkogka, A., Shchetynsky, K., Harroud, A., Gyllenberg, A., Liu, Y., Boddul, S., James, T., Sorosina, M., Filippi, M., Esposito, F., Wermeling, F., Gustafsson, M., Casaccia, P., Hillert, J., Olsson, T., Kockum, I., Sellgren, C.M., Golzio, C., Kular, L., Jagodic, M. (2024) A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis. Nature communications. 15:64196419
- Asad, Z., Pandey, A., Babu, A., Sun, Y., Shevade, K., Kapoor, S., Ullah, I., Ranjan, S., Scaria, V., Bajpai, R., Sachidanandan, C. (2016) Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation. Human molecular genetics. 25(16):3539-3554
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 5 of 5
Show