Gene
parn
- ID
- ZDB-GENE-040426-880
- Name
- poly(A)-specific ribonuclease (deadenylation nuclease)
- Symbol
- parn Nomenclature History
- Previous Names
-
- zgc:56067
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity; cation binding activity; and poly(A)-specific ribonuclease activity. Acts upstream of or within hemopoiesis. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 6. Orthologous to human PARN (poly(A)-specific ribonuclease).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56067 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Dhanraj et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive dyskeratosis congenita 6 | Alliance | Dyskeratosis congenita, autosomal recessive 6 | 616353 |
| Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4 | 616371 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001374 | R3H domain |
| Domain | IPR014789 | Poly(A)-specific ribonuclease, RNA-binding |
| Domain | IPR034042 | PARN, R3H domain |
| Family | IPR006941 | Ribonuclease CAF1 |
| Family | IPR051181 | CAF1 family poly(A)-specific ribonucleases |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
| Homologous_superfamily | IPR036867 | R3H domain superfamily |
Domain Details Per Protein
| Protein | Length | CAF1 family poly(A)-specific ribonucleases | Nucleotide-binding alpha-beta plait domain superfamily | PARN, R3H domain | Poly(A)-specific ribonuclease, RNA-binding | R3H domain | R3H domain superfamily | Ribonuclease CAF1 | Ribonuclease H-like superfamily | Ribonuclease H superfamily | RNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IHL6
|
647 | ||||||||||
|
UniProtKB:A0A0R4IW61
|
660 | ||||||||||
|
UniProtKB:Q7ZU92
|
660 |
Interactions and Pathways
No data available
Plasmids