Gene

poglut2

ID

ZDB-GENE-040426-878

Name

protein O-glucosyltransferase 2

Symbol

poglut2 Nomenclature History

Previous Names

kdelc1
zgc:56065 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. Orthologous to human POGLUT2 (protein O-glucosyltransferase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56065 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa11280	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With poglut2 Human Ortholog

No data available

Associated With poglut2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006598	Glycosyl transferase CAP10 domain
Family	IPR051091	Protein O-Glucosyltransferase/Glycosyltransferase 90
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Repeat	IPR001298	Filamin/ABP280 repeat
Repeat	IPR017868	Filamin/ABP280 repeat-like

Domain Details Per Protein

Protein	Additional Resources	Length	Filamin/ABP280 repeat	Filamin/ABP280 repeat-like	Glycosyl transferase CAP10 domain	Immunoglobulin E-set	Immunoglobulin-like fold	Protein O-Glucosyltransferase/Glycosyltransferase 90
UniProtKB:Q7ZVE6	InterPro	500

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 9

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kdelc1-201 (1) Ensembl	Ensembl		1,886 nt	Select Tool ZFIN BLAST
mRNA	kdelc1-202 (1) Ensembl	Ensembl		552 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-22A1	BX322637	ZFIN Curated Data
Contained in	BAC	DKEY-193N17	CR392351	ZFIN Curated Data
Encodes	cDNA	MGC:56065	BC045893	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200931 (1)	1765 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX322637 (1)	178563 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q7ZVE6 (1)	500 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	POGLUT2	13	Ensembl:ENSG00000134901 Gene:79070 HGNC:19350 OMIM:611613	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Poglut2	1	Ensembl:ENSMUSG00000026047 Gene:72050 MGI:1919300	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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