Gene

sdha

ID
ZDB-GENE-040426-874
Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Symbol
sdha Nomenclature History
Previous Names
  • im:7141001
  • zgc:56051
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to localize to mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Is expressed in several structures, including adaxial cell; alar plate midbrain region; eye; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sdha Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1GG Alliance Cardiomyopathy, dilated, 1GG 613642
mitochondrial complex II deficiency Alliance Mitochondrial complex II deficiency, nuclear type 1 252011
paraganglioma Alliance Paragangliomas 5 614165
Neurodegeneration with ataxia and late-onset optic atrophy 619259
Associated With sdha Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
Domain IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain
Domain IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
Family IPR011281 Succinate dehydrogenase, flavoprotein subunit
Family IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Homologous_superfamily IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Homologous_superfamily IPR037099 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily
Domain Details Per Protein
Protein Length FAD-dependent oxidoreductase 2, FAD binding domain FAD/NAD(P)-binding domain superfamily Fumarate reductase/succinate dehydrogenase, FAD-binding site Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily Succinate dehydrogenase, flavoprotein subunit Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
UniProtKB:B2GQ13 661
UniProtKB:Q7ZVF3 661
UniProtKB:Q6TNQ9 663
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations