Gene
sdha
- ID
- ZDB-GENE-040426-874
- Name
- succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
- Symbol
- sdha Nomenclature History
- Previous Names
-
- im:7141001
- zgc:56051
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to localize to mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; mitochondrial complex II deficiency; and paraganglioma. Is expressed in several structures, including adaxial cell; alar plate midbrain region; eye; musculature system; and pleuroperitoneal region. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141001 (1 image)
- IMAGE:6897154 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1GG | Alliance | Cardiomyopathy, dilated, 1GG | 613642 |
| mitochondrial complex II deficiency | Alliance | Mitochondrial complex II deficiency, nuclear type 1 | 252011 |
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 5 | 614165 |
| Neurodegeneration with ataxia and late-onset optic atrophy | 619259 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR003952 | Fumarate reductase/succinate dehydrogenase, FAD-binding site |
| Domain | IPR003953 | FAD-dependent oxidoreductase 2, FAD binding domain |
| Domain | IPR015939 | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal |
| Family | IPR011281 | Succinate dehydrogenase, flavoprotein subunit |
| Family | IPR014006 | Succinate dehydrogenase/fumarate reductase, flavoprotein subunit |
| Family | IPR030664 | FAD-dependent oxidoreductase SdhA/FrdA/AprA |
| Homologous_superfamily | IPR027477 | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR037099 | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | FAD-dependent oxidoreductase 2, FAD binding domain | FAD-dependent oxidoreductase SdhA/FrdA/AprA | FAD/NAD(P)-binding domain superfamily | Fumarate reductase/succinate dehydrogenase, FAD-binding site | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily | Succinate dehydrogenase, flavoprotein subunit | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily | Succinate dehydrogenase/fumarate reductase, flavoprotein subunit |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVF3
|
661 | |||||||||
|
UniProtKB:B2GQ13
|
661 |
Interactions and Pathways
No data available
Plasmids
No data available