Gene
eps8a
- ID
- ZDB-GENE-040426-871
- Name
- EGFR pathway substrate 8a, signaling adaptor
- Symbol
- eps8a Nomenclature History
- Previous Names
-
- eps8
- zgc:56041 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be active in ruffle membrane. Is expressed in nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56041 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 102 | Alliance | ?Deafness, autosomal recessive 102 | 615974 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR006020 | PTB/PI domain |
| Domain | IPR013625 | Tensin/EPS8 phosphotyrosine-binding domain |
| Domain | IPR033928 | Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain |
| Domain | IPR035462 | Eps8, SH3 domain |
| Domain | IPR041418 | SAM domain |
| Domain | IPR055093 | EPS8, spectrin-like domain |
| Family | IPR039801 | Epidermal growth factor receptor kinase substrate 8-like |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available