Gene

atp5mc3a

ID

ZDB-GENE-040426-857

Name

ATP synthase membrane subunit c locus 3a

Symbol

atp5mc3a Nomenclature History

Previous Names

atp5g3
atp5g3a
zgc:55970
zgc:86872

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in ATP synthesis coupled proton transport. Predicted to localize to mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Human ortholog(s) of this gene implicated in renal cell carcinoma and urinary bladder cancer. Orthologous to several human genes including ATP5MC3 (ATP synthase membrane subunit c locus 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp5mc3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
early-onset dystonia and/or spastic paraplegia	Alliance	Dystonia, early-onset, and/or spastic paraplegia	619681

Associated With atp5mc3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020537	ATP synthase, F0 complex, subunit C, DCCD-binding site
Domain	IPR002379	V-ATPase proteolipid subunit C-like domain
Family	IPR000454	ATP synthase, F0 complex, subunit C
Homologous_superfamily	IPR035921	F/V-ATP synthase subunit C superfamily
Homologous_superfamily	IPR038662	F1F0 ATP synthase subunit C superfamily

Domain Details Per Protein

Protein	Length	ATP synthase, F0 complex, subunit C	ATP synthase, F0 complex, subunit C, DCCD-binding site	F1F0 ATP synthase subunit C superfamily	F/V-ATP synthase subunit C superfamily	V-ATPase proteolipid subunit C-like domain
UniProtKB:Q7ZYW7 InterPro	139

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atp5mc3a-201 (1) Ensembl	Havana	1322 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	atp5mc3a-202 (1) Ensembl	Havana	850 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	atp5g3a-003 (1) Ensembl	Havana	840 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations