Gene
rnf8
- ID
- ZDB-GENE-040426-849
- Name
- ring finger protein 8, E3 ubiquitin protein ligase
- Symbol
- rnf8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including histone binding activity; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including DNA metabolic process; chromatin remodeling; and protein polyubiquitination. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in chromosome, telomeric region. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol; nucleus; and site of double-strand break. Is expressed in telencephalon. Orthologous to human RNF8 (ring finger protein 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55936 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR000253 | Forkhead-associated (FHA) domain |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR018957 | Zinc finger, C3HC4 RING-type |
| Family | IPR017335 | E3 ubiquitin-protein ligase RNF8 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase RNF8 | Forkhead-associated (FHA) domain | SMAD/FHA domain superfamily | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q803C1 | InterPro | 485 |
Interactions and Pathways
No data available
Plasmids
No data available