Gene
ciao1
- ID
- ZDB-GENE-040426-839
- Name
- cytosolic iron-sulfur assembly component 1
- Symbol
- ciao1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to be involved in iron-sulfur cluster assembly and protein maturation. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55911 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from van Karnebeek et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hsi21 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| la016412Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8858 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Multiple mitochondrial dysfunctions syndrome 10 | 620960 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Family | IPR028608 | Probable cytosolic iron-sulfur protein assembly protein, CIAO1/Cia1 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Probable cytosolic iron-sulfur protein assembly protein, CIAO1/Cia1 | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P0D9 | InterPro | 330 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-294L19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55911 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77394 | ||
| Encodes | cDNA | MGC:198265 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198267 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200147 (1) | 1823 nt | ||
| Genomic | GenBank:BX571956 (1) | 285929 nt | ||
| Polypeptide | UniProtKB:Q6P0D9 (1) | 330 aa |
- van Karnebeek, C.D.M., Tarailo-Graovac, M., Leen, R., Meinsma, R., Correard, S., Jansen-Meijer, J., Prykhozhij, S.V., Pena, I.A., Ban, K., Schock, S., Saxena, V., Pras-Raves, M.L., Drögemöller, B.I., Grootemaat, A.E., van der Wel, N.N., Dobritzsch, D., Roseboom, W., Schomakers, B.V., Jaspers, Y.R.J., Zoetekouw, L., Roelofsen, J., Ferreira, C.R., van der Lee, R., Ross, C.J., Kochan, J., McIntyre, R.L., van Klinken, J.B., van Weeghel, M., Kramer, G., Weschke, B., Labrune, P., Willemsen, M.A., Riva, D., Garavaglia, B., Moeschler, J.B., Filiano, J.J., Ekker, M., Berman, J.N., Dyment, D., Vaz, F.M., Wassermann, W.W., Houtkooper, R.H., van Kuilenburg, A.B.P. (2024) CIAO1 and MMS19 deficiency: a lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders. Genetics in medicine : official journal of the American College of Medical Genetics. 26(6):101104
- Luo, J., Zhang, X., He, S., Lou, Q., Zhai, G., Shi, C., Yin, Z., Zheng, F. (2019) Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology. 28:101355
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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