Gene
cdc5l
- ID
- ZDB-GENE-040426-821
- Name
- CDC5 cell division cycle 5-like (S. pombe)
- Symbol
- cdc5l Nomenclature History
- Previous Names
-
- zgc:55853
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing; cell division; and mRNA processing. Predicted to be part of Prp19 complex and spliceosomal complex. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55853 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16815 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22983 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22984 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39137 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42854 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001005 | SANT/Myb domain |
| Domain | IPR017930 | Myb domain |
| Domain | IPR021786 | Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal |
| Domain | IPR047240 | Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain |
| Family | IPR047242 | Pre-mRNA splicing factor component CDC5L/Cef1 |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Myb domain | Pre-mRNA splicing factor component CDC5L/Cef1 | Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain | Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal | SANT/Myb domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q803E9 | InterPro | 567 | ||||||
| UniProtKB:E9QIC1 | InterPro | 800 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-370H15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-202E13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55853 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192369 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201084 (1) | 2799 nt | ||
| Genomic | GenBank:BX927095 (2) | 211277 nt | ||
| Polypeptide | UniProtKB:E9QIC1 (1) | 800 aa |
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Xue, Y., Lv, J., Zhang, C., Wang, L., Ma, D., Liu, F. (2017) The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b. Developmental Cell. 42(4):349-362.e4
- Zhang, Y., Xue, Y., Cao, C., Huang, J., Hong, Q., Hai, T., Jia, Q., Wang, X., Qin, G., Yao, J., Wang, X., Zheng, Q., Zhang, R., Li, Y., Luo, A., Zhang, N., Shi, G., Wang, Y., Ying, H., Liu, Z., Wang, H., Meng, A., Zhou, Q., Wei, H., Liu, F., Zhao, J. (2017) Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 130(20):2161-2170
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 5 of 5
Show