Gene

vldlr

ID
ZDB-GENE-040426-803
Name
very low density lipoprotein receptor
Symbol
vldlr Nomenclature History
Previous Names
  • lr8 (1)
  • zgc:55792
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and very-low-density lipoprotein particle receptor activity. Predicted to be involved in cholesterol metabolic process; endocytosis; and lipid transport. Predicted to localize to clathrin-coated pit; integral component of membrane; and very-low-density lipoprotein particle. Is expressed in several structures, including axis; brain; pronephric duct; retinal ganglion cell layer; and spinal cord interneuron. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, mental retardation and dysequlibrium syndrome; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vldlr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cerebellar ataxia, mental retardation and dysequlibrium syndrome Alliance Cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 224050
Associated With vldlr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR032931 Very low-density lipoprotein receptor
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR036055 LDL receptor-like superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000033 LDLR class B repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site LDLR class B repeat LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Six-bladed beta-propeller, TolB-like Very low-density lipoprotein receptor
UniProtKB:A0A2R8QKQ1 856
UniProtKB:A0A2R8QJ78 844
UniProtKB:E7FF13 866
UniProtKB:E9QBA5 842
UniProtKB:A0A0R4IGN2 863
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations