Gene
vldlr
- ID
- ZDB-GENE-040426-803
- Name
- very low density lipoprotein receptor
- Symbol
- vldlr Nomenclature History
- Previous Names
-
- lr8 (1)
- zgc:55792
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable apolipoprotein binding activity. Predicted to act upstream of or within endocytosis. Predicted to be located in clathrin-coated pit. Predicted to be active in plasma membrane. Is expressed in axis; central nervous system; immature eye; pronephric duct; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55792 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1 | Alliance | Cerebellar hypoplasia, impaired intellectual development, and dysequilibrium syndrome 1 | 224050 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR051221 | Low-density lipoprotein receptor-related |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Low-density lipoprotein receptor-related | NOTCH1 EGF-like calcium-binding domain | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B1M8 | InterPro | 877 | |||||||||||
| UniProtKB:A0A8M9PTE7 | InterPro | 856 | |||||||||||
| UniProtKB:A0A8M2B226 | InterPro | 874 | |||||||||||
| UniProtKB:E7FF13 | InterPro | 866 | |||||||||||
| UniProtKB:A0A0R4IGN2 | InterPro | 863 | |||||||||||
| UniProtKB:E9QBA5 | InterPro | 842 | |||||||||||
| UniProtKB:A0AB32U266 | InterPro | 839 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vldlr-201
(1)
|
Ensembl | 3,751 nt | ||
| mRNA |
vldlr-203
(1)
|
Ensembl | 3,496 nt | ||
| mRNA |
vldlr-205
(1)
|
Ensembl | 4,074 nt | ||
| mRNA |
vldlr-206
(1)
|
Ensembl | 4,053 nt | ||
| mRNA |
vldlr-207
(1)
|
Ensembl | 4,132 nt | ||
| ncRNA |
vldlr-002
(1)
|
Ensembl | 921 nt | ||
| ncRNA |
vldlr-003
(1)
|
Ensembl | 752 nt |
Interactions and Pathways
No data available
Plasmids
No data available