Gene
vldlr
- ID
- ZDB-GENE-040426-803
- Name
- very low density lipoprotein receptor
- Symbol
- vldlr Nomenclature History
- Previous Names
-
- lr8 (1)
- zgc:55792
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable apolipoprotein binding activity. Predicted to act upstream of or within endocytosis. Predicted to be located in clathrin-coated pit. Predicted to be active in plasma membrane. Is expressed in axis; central nervous system; immature eye; pronephric duct; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55792 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ic3030 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| sa14068 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17714 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38785 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tud25Gt | Transgenic insertion | Intron 2 | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vldlr | (3) | |
| CRISPR2-vldlr | Höijer et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1 | Alliance | Cerebellar hypoplasia, impaired intellectual development, and dysequilibrium syndrome 1 | 224050 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
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Domain Details Per Protein
| Protein | Length | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Low-density lipoprotein receptor | NOTCH1 EGF-like calcium-binding domain | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B1M8
|
877 | |||||||||||
|
UniProtKB:A0A8M9PTE7
|
856 | |||||||||||
|
UniProtKB:A0A8M2B226
|
874 | |||||||||||
|
UniProtKB:E7FF13
|
866 | |||||||||||
|
UniProtKB:A0A0R4IGN2
|
863 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-241O7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55792 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200923 (1) | 3751 nt | ||
| Genomic | GenBank:CR628386 (1) | 148044 nt | ||
| Polypeptide | UniProtKB:A0A8M2B1M8 (1) | 877 aa |
- Liu, Z., Zhang, N., Wang, C., Shi, L., Hu, Y., Wang, Y., Li, J. (2024) Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish†. Biology of reproduction. 111(1):123-134
- Höijer, I., Emmanouilidou, A., Östlund, R., van Schendel, R., Bozorgpana, S., Tijsterman, M., Feuk, L., Gyllensten, U., den Hoed, M., Ameur, A. (2022) CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Nature communications. 13:627
- Nimura, T., Itoh, T., Hagio, H., Hayashi, T., Di Donato, V., Takeuchi, M., Itoh, T., Inoguchi, F., Sato, Y., Yamamoto, N., Katsuyama, Y., Del Bene, F., Shimizu, T., Hibi, M. (2019) Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Developmental Biology. 455(2):393-408
- Vecchia, E.D., Donato, V.D., Young, A.M.J., Bene, F.D., Norton, W.H.J. (2019) Reelin Signaling Controls the Preference for Social Novelty in Zebrafish. Frontiers in behavioral neuroscience. 13:214
- Di Donato, V., De Santis, F., Albadri, S., Auer, T.O., Duroure, K., Charpentier, M., Concordet, J.P., Gebhardt, C., Del Bene, F. (2018) An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System. Neuron. 97(5):1049-1062.e6
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jungke, P., Hammer, J., Hans, S., Brand, M. (2015) Isolation of Novel CreERT2-Driver Lines in Zebrafish Using an Unbiased Gene Trap Approach. PLoS One. 10:e0129072
- Reading, B.J., Hiramatsu, N., Schilling, J., Molloy, K.T., Glassbrook, N., Mizuta, H., Luo, W., Baltzegar, D.A., Williams, V.N., Todo, T., Hara, A., Sullivan, C.V. (2014) Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenins in teleost fishes. Journal of Lipid Research. 55(11):2287-95
- Zhang, P., Yao, Q., Lu, L., Li, Y., Chen, P.J., Duan, C. (2014) Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Reports. 6:1110-21
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