Gene
umps
- ID
- ZDB-GENE-040426-785
- Name
- uridine monophosphate synthetase
- Symbol
- umps Nomenclature History
- Previous Names
-
- zgc:55702 (1)
- zgc:55723
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Predicted to be involved in UMP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to act upstream of or within 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine nucleotide biosynthetic process. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55723 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| orotic aciduria | Alliance | Orotic aciduria | 258900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018089 | Orotidine 5'-phosphate decarboxylase, active site |
| Domain | IPR000836 | Phosphoribosyltransferase domain |
| Domain | IPR001754 | Orotidine 5'-phosphate decarboxylase domain |
| Domain | IPR004467 | Orotate phosphoribosyl transferase domain |
| Family | IPR014732 | Orotidine 5'-phosphate decarboxylase |
| Family | IPR023031 | Orotate phosphoribosyltransferase |
| Homologous_superfamily | IPR011060 | Ribulose-phosphate binding barrel |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR029057 | Phosphoribosyltransferase-like |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Orotate phosphoribosyltransferase | Orotate phosphoribosyl transferase domain | Orotidine 5'-phosphate decarboxylase | Orotidine 5'-phosphate decarboxylase, active site | Orotidine 5'-phosphate decarboxylase domain | Phosphoribosyltransferase domain | Phosphoribosyltransferase-like | Ribulose-phosphate binding barrel |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JLL1
|
479 |
Interactions and Pathways
No data available
Plasmids
No data available