Gene

picalma

ID

ZDB-GENE-040426-761

Name

phosphatidylinositol binding clathrin assembly protein a

Symbol

picalma Nomenclature History

Previous Names

picalm
zgc:55615

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to act upstream of or within clathrin coat assembly and endocytosis. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55615 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With picalma Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, somatic	601626

Associated With picalma Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011417	AP180 N-terminal homology (ANTH) domain
Domain	IPR013809	ENTH domain
Family	IPR045192	Clathrin coat assembly protein AP180-like
Homologous_superfamily	IPR008942	ENTH/VHS
Homologous_superfamily	IPR014712	ANTH domain superfamily

Domain Details Per Protein

Protein	Length	ANTH domain superfamily	AP180 N-terminal homology (ANTH) domain	Clathrin coat assembly protein AP180-like	ENTH domain	ENTH/VHS
UniProtKB:A0A8M3B3B6 InterPro	728
UniProtKB:A0A8M3B3B4 InterPro	710
UniProtKB:A0A8M9Q5T8 InterPro	718
UniProtKB:A0A8M9PTF3 InterPro	733
UniProtKB:A0A8M3BD23 InterPro	615
UniProtKB:A0A8M9QKL0 InterPro	665
UniProtKB:A0A8M3AWT2 InterPro	732
UniProtKB:A0A8M9QGG0 InterPro	640
UniProtKB:A0A8M9QKK5 InterPro	740
UniProtKB:A0A8M3B698 InterPro	579
UniProtKB:A0A8M9PTF8 InterPro	638
UniProtKB:A0A8M9Q5T5 InterPro	744
UniProtKB:A0A8M3AWV7 InterPro	736
UniProtKB:A0A8M9Q5U3 InterPro	736
UniProtKB:A0A8M9QKL4 InterPro	630
UniProtKB:A0A8M9PTG3 InterPro	623
UniProtKB:A0A8M3AWV9 InterPro	622
UniProtKB:F1QKW9 InterPro	589
UniProtKB:Q7ZVU6 InterPro	589
UniProtKB:A0A8M9QGG5 InterPro	627
UniProtKB:A0A8M9QGF6 InterPro	740
UniProtKB:A0A8M9QBW5 InterPro	716
UniProtKB:A0A8M3B694 InterPro	725
UniProtKB:A0A8M9QBX0 InterPro	634
UniProtKB:A0A8M9QBW1 InterPro	742
UniProtKB:A0A8M9Q5U0 InterPro	634

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	picalma-201 (1) Ensembl	Ensembl	3,477 nt	Select Tool ZFIN BLAST
mRNA	picalma-202 (1) Ensembl	Ensembl	2,222 nt	Select Tool ZFIN BLAST
mRNA	picalma-203 (1) Ensembl	Ensembl	2,220 nt	Select Tool ZFIN BLAST
mRNA	picalma-204 (1) Ensembl	Ensembl	825 nt	Select Tool ZFIN BLAST
mRNA	picalma-205 (1) Ensembl	Ensembl	566 nt	Select Tool ZFIN BLAST
mRNA	picalma-206 (1) Ensembl	Ensembl	2,534 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations