Gene

mkks

ID

ZDB-GENE-040426-757

Name

MKKS centrosomal shuttling protein

Symbol

mkks Nomenclature History

Previous Names

bbs6
zgc:55608

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and unfolded protein binding activity. Involved in several processes, including embryonic morphogenesis; establishment of pigment granule localization; and sensory organ development. Localizes to cytoplasm and nucleus. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 6; McKusick-Kaufman syndrome; congenital heart disease; and obesity. Orthologous to human MKKS (McKusick-Kaufman syndrome).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55608 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mkks Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bardet-Biedl syndrome 6	Alliance	Bardet-Biedl syndrome 6	605231
McKusick-Kaufman syndrome	Alliance	McKusick-Kaufman syndrome	236700

Associated With mkks Via Experimental Models

Human Disease	Fish	Conditions	Citations
ciliopathy	WT + MO1-mkks	control	Tobin et al., 2008

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002423	Chaperonin Cpn60/GroEL/TCP-1 family
Family	IPR028790	Molecular chaperone MKKS
Homologous_superfamily	IPR027409	GroEL-like apical domain superfamily
Homologous_superfamily	IPR027410	TCP-1-like chaperonin intermediate domain superfamily
Homologous_superfamily	IPR027413	GroEL-like equatorial domain superfamily