Gene
irak4
- ID
- ZDB-GENE-040426-738
- Name
- interleukin-1 receptor-associated kinase 4
- Symbol
- irak4 Nomenclature History
- Previous Names
-
- zgc:55553
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Acts upstream of or within positive regulation of DNA-templated transcription and response to bacterium. Predicted to be located in cytoplasm. Is expressed in brain; gill; heart; immune system; and liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7161258 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency 67 | 607676 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR037970 | IRAK4, Death domain |
| Family | IPR017428 | Interleukin-1 receptor-associated kinase 4 |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Death-like domain superfamily | Interleukin-1 receptor-associated kinase 4 | IRAK4, Death domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IP49 | InterPro | 481 | |||||||
| UniProtKB:A0A0R4IQ44 | InterPro | 447 | |||||||
| UniProtKB:A0A0R4IF68 | InterPro | 382 | |||||||
| UniProtKB:Q7ZVW7 | InterPro | 382 |
1 - 4 of 4
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Weng, P., Lan, M., Zhang, H., Fan, H., Wang, X., Ran, C., Yue, Z., Hu, J., Xu, A., Huang, S. (2024) Both IRAK3 and IRAK1 Activate the MyD88-TRAF6 Pathway in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 213(3):362-372
- Li, Y., Shah, R.B., Sarti, S., Belcher, A.L., Lee, B.J., Gorbatenko, A., Nemati, F., Yu, H., Stanley, Z., Rahman, M., Shao, Z., Silva, J.M., Zha, S., Sidi, S. (2023) A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling. Science signaling. 16:eadh3449eadh3449
- Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. The Science of the total environment. 702:134969
- Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Parental transfer of microcystin-LR induced innate immune dysfunction of zebrafish: A cross-generational study. Environmental science & technology. 54(2):1014-1023
- Liu, P.H., Shah, R.B., Li, Y., Arora, A., Ung, P.M., Raman, R., Gorbatenko, A., Kozono, S., Zhou, X.Z., Brechin, V., Barbaro, J.M., Thompson, R., White, R.M., Aguirre-Ghiso, J.A., Heymach, J.V., Lu, K.P., Silva, J.M., Panageas, K.S., Schlessinger, A., Maki, R.G., Skinner, H.D., de Stanchina, E., Sidi, S. (2019) An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nature cell biology. 21(2):203-213
- Wu, C., Xu, X., Zhi, X., Jiang, Z., Li, Y., Xie, X., Chen, X., Hu, C. (2019) Identification and functional characterization of IRAK-4 in grass carp (Ctenopharyngodon idellus). Fish & shellfish immunology. 87:438-448
- Chandrarathna, H.P.S.U., Nikapitiya, C., Dananjaya, S.H.S., Wijerathne, C.U.B., Wimalasena, S.H.M.P., Kwon, H.J., Heo, G.J., Lee, J., De Zoysa, M. (2018) Outcome of co-infection with opportunistic and multidrug resistant Aeromonas hydrophila and A. veronii in zebrafish: Identification, characterization, pathogenicity and immune responses. Fish & shellfish immunology. 80:573-581
- Wei, J., Zhou, T., Hu, Z., Li, Y., Yuan, H., Zhao, K., Zhang, H., Liu, C. (2018) Effects of triclocarban on oxidative stress and innate immune response in zebrafish embryos. Chemosphere. 210:93-101
- Srivastava, N., Shelly, A., Kumar, M., Pant, A., Das, B., Majumdar, T., Mazumder, S. (2017) Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish.. Cell death discovery. 3:17067
1 - 10 of 20
Show