Gene
manba
- ID
- ZDB-GENE-040426-721
- Name
- mannosidase, beta A, lysosomal
- Symbol
- manba Nomenclature History
- Previous Names
-
- zgc:55493 (1)
- zgc:76896
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Predicted to localize to lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55493 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ko et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| beta-mannosidosis | Alliance | Mannosidosis, beta | 248510 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006102 | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich |
| Domain | IPR006103 | Glycoside hydrolase family 2, catalytic domain |
| Domain | IPR041447 | Mannosidase Ig/CBM-like domain |
| Domain | IPR041625 | Beta-mannosidase, Ig-fold domain |
| Family | IPR050887 | Beta-mannosidase glycosyl hydrolases |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
| Homologous_superfamily | IPR036156 | Beta-Galactosidase/glucuronidase domain superfamily |
Domain Details Per Protein
| Protein | Length | Beta-Galactosidase/glucuronidase domain superfamily | Beta-mannosidase glycosyl hydrolases | Beta-mannosidase, Ig-fold domain | Galactose-binding-like domain superfamily | Glycoside hydrolase family 2, catalytic domain | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich | Glycoside hydrolase superfamily | Immunoglobulin-like fold | Mannosidase Ig/CBM-like domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVY7
|
901 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available