Gene
stau2
- ID
- ZDB-GENE-040426-687
- Name
- staufen double-stranded RNA binding protein 2
- Symbol
- stau2 Nomenclature History
- Previous Names
-
- zgc:55287 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable double-stranded RNA binding activity and mRNA binding activity. Acts upstream of or within germ cell development and germ cell migration. Predicted to be located in microtubule. Predicted to be active in several cellular components, including cytoplasmic stress granule; neuron projection; and neuronal cell body. Is expressed in midbrain; oocyte; and otic vesicle. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55287 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011012Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014501Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa113 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24458 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44106 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-stau2 | N/A | Ramasamy et al., 2006 |
| MO2-stau2 | N/A | Ramasamy et al., 2006 |
| MO3-stau2 | N/A | Ramasamy et al., 2006 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR032478 | Staufen, C-terminal |
| Domain | IPR044464 | Staufen 2, second double-stranded RNA binding domain |
| Domain | IPR044473 | Staufen 2, third double-stranded RNA binding domain |
| Domain | IPR044474 | Staufen 2, fourth double-stranded RNA binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Double-stranded RNA-binding domain | Double-stranded RNA-binding domain-containing protein | Staufen 2, first double-stranded RNA binding domain | Staufen 2, fourth double-stranded RNA binding domain | Staufen 2, second double-stranded RNA binding domain | Staufen 2, third double-stranded RNA binding domain | Staufen, C-terminal |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AVY7 | InterPro | 654 | |||||||
| UniProtKB:Q7ZW47 | InterPro | 606 | |||||||
| UniProtKB:F1QJT6 | InterPro | 678 | |||||||
| UniProtKB:A0A8M9PTX0 | InterPro | 684 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-171B20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-233I23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-11P5 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-28D2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55287 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200925 (1) | 3179 nt | ||
| Genomic | GenBank:BX247906 (1) | 213917 nt | ||
| Polypeptide | UniProtKB:A0A8M9PTX0 (1) | 684 aa |
- Taylor, R., Hamid, F., Fielding, T., Gordon, P.M., Maloney, M., Makeyev, E.V., Houart, C. (2022) Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Nature communications. 13:69946994
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Ramasamy, S., Wang, H., Quach, H.N., and Sampath, K. (2006) Zebrafish Staufen1 and Staufen2 are required for the survival and migration of primordial germ cells. Developmental Biology. 292(2):393-406
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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