Gene
nck2a
- ID
- ZDB-GENE-040426-686
- Name
- NCK adaptor protein 2a
- Symbol
- nck2a Nomenclature History
- Previous Names
-
- zgc:55283 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and signaling adaptor activity. Predicted to be involved in regulation of response to endoplasmic reticulum stress and regulation of translation. Predicted to act upstream of or within actin filament bundle assembly; barbed-end actin filament capping; and regulation of translation. Predicted to be located in cytosol and endoplasmic reticulum. Is expressed in rhombomere 3 and rhombomere 5. Orthologous to human NCK2 (NCK adaptor protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Choe et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR035559 | Nck2, SH3 domain 1 |
| Domain | IPR035561 | Nck2, SH3 domain 3 |
| Domain | IPR035883 | Nck2, SH2 domain |
| Family | IPR017304 | Cytoplasmic protein NCK |
| Family | IPR051184 | Tyrosine-phosphorylated adapter molecule |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Cytoplasmic protein NCK | Nck2, SH2 domain | Nck2, SH3 domain 1 | Nck2, SH3 domain 3 | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-phosphorylated adapter molecule |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q4I8
|
403 | |||||||||
|
UniProtKB:Q803A2
|
403 |
Interactions and Pathways
No data available
Plasmids
No data available