Gene
tyms
- ID
- ZDB-GENE-040426-59
- Name
- thymidylate synthetase
- Symbol
- tyms Nomenclature History
- Previous Names
-
- zgc:56465
- zgc:77659
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables thymidylate synthase activity. Acts upstream of or within dTMP biosynthetic process and retina development in camera-type eye. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including anterior neural tube; blood; nervous system; optic vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; digenic dyskeratosis congenita; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56465 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| digenic dyskeratosis congenita | Alliance | Dyskeratosis congenita, digenic | 620040 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020940 | Thymidylate synthase, active site |
| Domain | IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain |
| Family | IPR000398 | Thymidylate synthase |
| Family | IPR045097 | Thymidylate synthase/dCMP hydroxymethylase |
| Homologous_superfamily | IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Thymidylate synthase | Thymidylate synthase, active site | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase domain | Thymidylate synthase/dCMP hydroxymethylase superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P045 | InterPro | 318 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-310J3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56465 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77659 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131760 (1) | 1239 nt | ||
| Genomic | GenBank:FP016237 (2) | 90568 nt | ||
| Polypeptide | UniProtKB:Q6P045 (1) | 318 aa |
- Frisk, J.H., Örn, S., Pejler, G., Eriksson, S., Wang, L. (2022) Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders. BMC Neuroscience. 23:19
- van der Ven, L.T.M., Schoonen, W.G., Groot, R.M., den Ouden, F., Heusinkveld, H.J., Zwart, E.P., Hodemaekers, H.M., Rorije, E., de Knecht, J. (2020) The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish. Toxicology and applied pharmacology. 407:115249
- Loponte, S., Segré, C.V., Senese, S., Miccolo, C., Santaguida, S., Deflorian, G., Citro, S., Mattoscio, D., Pisati, F., Moser, M.A., Visintin, R., Seiser, C., Chiocca, S. (2016) Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Scientific Reports. 6:30213
- Coxam, B., Neyt, C., Grassini, D.R., Le Guen, L., Smith, K.A., Schulte-Merker, S., Hogan, B.M. (2015) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(1):1-9
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mans, D.A., Vermaat, J.S., Weijts, B.G., van Rooijen, E., van Reeuwijk, J., Boldt, K., Daenen, L.G., van der Groep, P., Rowland, B.D., Jans, J.J., Roepman, R., Voest, E.E., van Diest, P.J., Verhaar, M.C., de Bruin, A., and Giles, R.H. (2013) Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. The Journal of pathology. 231(1):117-29
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
- Lee, M.S., Bonner, J.R., Bernard, D.J., Sanchez, E.L., Sause, E.T., Prentice, R.R., Burgess, S.M., and Brody, L.C. (2012) Disruption of the folate pathway in zebrafish causes developmental defects. BMC Developmental Biology. 12(1):12
- Liu, W., Chen, J.R., Hsu, C.H., Li, Y.H., Chen, Y.M., Lin, C.Y., Huang, S.J., Chang, Z.K., Chen, Y.C., Lin, C.H., Gong, H.Y., Lin, C.C., Kawakami, K., and Wu, J.L. (2012) A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. Hepatology (Baltimore, Md.). 56(6):2268-2276
- Sucularli, C., Senturk, S., Ozturk, M., and Konu, O. (2011) Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment. Molecular biology reports. 38(6):4111-23
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