Gene
nup133
- ID
- ZDB-GENE-040426-2941
- Name
- nucleoporin 133
- Symbol
- nup133 Nomenclature History
- Previous Names
-
- wu:fa04e09
- zgc:55311
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore distribution; nucleocytoplasmic transport; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to colocalize with condensed chromosome kinetochore. Used to study Galloway-Mowat syndrome. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human NUP133 (nucleoporin 133).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 18 | Alliance | Nephrotic syndrome, type 18 | 618177 |
| ?Galloway-Mowat syndrome 8 | 618349 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Galloway-Mowat syndrome 1 | WT + MO1-nup133 | standard conditions | Fujita et al., 2018 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nuclear pore complex protein Nup133-like | Nucleoporin, Nup133/Nup155-like, C-terminal | Nucleoporin, Nup133/Nup155-like, N-terminal | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:F1QNV4
|
1136 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nup133-201
(1)
|
Ensembl | 3,659 nt |
Interactions and Pathways
No data available
Plasmids
No data available