Gene
nup133
- ID
- ZDB-GENE-040426-2941
- Name
- nucleoporin 133
- Symbol
- nup133 Nomenclature History
- Previous Names
-
- wu:fa04e09
- zgc:55311
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of nuclear pore. Predicted to be involved in poly(A)+ mRNA export from nucleus; protein import into nucleus; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in kinetochore and nucleus. Predicted to be part of nuclear pore outer ring. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Used to study Galloway-Mowat syndrome 1. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 18 | Alliance | Nephrotic syndrome, type 18 | 618177 |
| ?Galloway-Mowat syndrome 8 | 618349 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Galloway-Mowat syndrome 1 | WT + MO1-nup133 | standard conditions | Fujita et al., 2018 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nuclear pore complex protein Nup133-like | Nucleoporin, Nup133/Nup155-like, C-terminal | Nucleoporin, Nup133/Nup155-like, N-terminal | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:F1QNV4
|
1136 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nup133-201
(1)
|
Ensembl | 3,659 nt |
Interactions and Pathways
No data available
Plasmids
No data available