Gene
mus81
- ID
- ZDB-GENE-040426-2923
- Name
- MUS81 structure-specific endonuclease subunit
- Symbol
- mus81 Nomenclature History
- Previous Names
-
- wu:fc26g01
- zgc:66489
- zgc:91801
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction endodeoxyribonuclease activity. Predicted to be involved in double-strand break repair via break-induced replication; mitotic intra-S DNA damage checkpoint signaling; and resolution of meiotic recombination intermediates. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66489 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006166 | ERCC4 domain |
| Domain | IPR047416 | MUS81, XPF-like nuclease domain |
| Domain | IPR047417 | MUS81, winged helix domain |
| Family | IPR033309 | Crossover junction endonuclease Mus81 |
| Homologous_superfamily | IPR011335 | Restriction endonuclease type II-like |
| Homologous_superfamily | IPR027421 | DNA polymerase lambda lyase domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR042530 | EME1/EME2, C-terminal domain |
Domain Details Per Protein
| Protein | Length | Crossover junction endonuclease Mus81 | DNA polymerase lambda lyase domain superfamily | EME1/EME2, C-terminal domain | ERCC4 domain | MUS81, winged helix domain | MUS81, XPF-like nuclease domain | Restriction endonuclease type II-like | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6GML8
|
612 | ||||||||
|
UniProtKB:Q7SXA9
|
604 |
Interactions and Pathways
No data available
Plasmids
No data available