ZFIN is now using GRCz12tu for Genomic Data
Gene
far1
- ID
- ZDB-GENE-040426-2908
- Name
- fatty acyl CoA reductase 1
- Symbol
- far1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Is expressed in several structures, including nervous system; notochord; pronephric duct; solid lens vesicle; and ventral mesenchyme. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to human FAR1 (fatty acyl-CoA reductase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55416 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| rhizomelic chondrodysplasia punctate type 4 | Alliance | Peroxisomal fatty acyl-CoA reductase 1 disorder | 616154 |
| Cataracts, spastic paraparesis, and speech delay | 619338 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fatty acyl-CoA reductase | Fatty acyl-CoA reductase, C-terminal | Fatty acyl-coenzyme A reductase-like, NAD-binding domain | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PMN6 | InterPro | 518 | ||||
| UniProtKB:A0A8M2BLL5 | InterPro | 518 | ||||
| UniProtKB:Q803W3 | InterPro | 432 | ||||
| UniProtKB:A0A8M9PYB3 | InterPro | 400 |
Interactions and Pathways
No data available
Plasmids
No data available