Gene
far1
- ID
- ZDB-GENE-040426-2908
- Name
- fatty acyl CoA reductase 1
- Symbol
- far1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Is expressed in several structures, including nervous system; notochord; pronephric duct; solid lens vesicle; and ventral mesenchyme. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to human FAR1 (fatty acyl-CoA reductase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55416 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| rhizomelic chondrodysplasia punctate type 4 | Alliance | Peroxisomal fatty acyl-CoA reductase 1 disorder | 616154 |
| Cataracts, spastic paraparesis, and speech delay | 619338 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fatty acyl-CoA reductase | Fatty acyl-CoA reductase, C-terminal | Fatty acyl-coenzyme A reductase-like, NAD-binding domain | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PMN6 | InterPro | 518 | ||||
| UniProtKB:A0A8M2BLL5 | InterPro | 518 | ||||
| UniProtKB:Q803W3 | InterPro | 432 | ||||
| UniProtKB:A0A8M9PYB3 | InterPro | 400 |
Interactions and Pathways
No data available
Plasmids
No data available