Gene
dnaja2a
- ID
- ZDB-GENE-040426-2884
- Name
- DnaJ heat shock protein family (Hsp40) member A2a
- Symbol
- dnaja2a Nomenclature History
- Previous Names
-
- dnaja2
- wu:fb59e04
- wu:fb60b08
- zgc:55486
- zgc:85775 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to act upstream of or within protein folding and response to heat. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in brain; neurons; and proliferative region. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55486 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa21047 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Chaperone DnaJ | Chaperone DnaJ, C-terminal | Chaperone J-domain superfamily | DnaJ domain | DnaJ domain, conserved site | DnaJ homolog subfamily A member 1/2-like | Heat shock protein DnaJ, cysteine-rich domain | Heat shock protein DnaJ, cysteine-rich domain superfamily | HSP40/DnaJ peptide-binding |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7ZUP5 | InterPro | 412 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
dnaja2-201
(1)
|
Ensembl | 1,984 nt | ||
mRNA |
dnaja2a-202
(1)
|
Ensembl | 2,334 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-283L9 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-297E17 | ZFIN Curated Data | |
Encodes | EST | fb59e04 | ||
Encodes | EST | fb60b08 | ||
Encodes | cDNA | MGC:55486 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85775 | ||
Encodes | cDNA | MGC:192880 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213493 (1) | 2353 nt | ||
Genomic | GenBank:CU672230 (1) | 107877 nt | ||
Polypeptide | UniProtKB:Q7ZUP5 (1) | 412 aa |
- Hassinen, M., Korajoki, H., Abramochkin, D., Krivosheya, P., Vornanen, M. (2019) Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 189(6):735-749
- Abramochkin, D.V., Hassinen, M., Vornanen, M. (2018) Transcripts of Kv7.1 and MinK channels and slow delayed rectifier K+ current (IKs) are expressed in zebrafish (Danio rerio) heart.. Pflugers Archiv : European journal of physiology. 470(12):1753-1764
- Haverinen, J., Hassinen, M., Dash, S.N., Vornanen, M. (2018) Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels. The Journal of experimental biology. 221(Pt 10)
- Haverinen, J., Hassinen, M., Korajoki, H., Vornanen, M. (2018) Cardiac voltage-gated sodium channel expression and electrophysiological characterization of the sodium current in the zebrafish (Danio rerio) ventricle. Progress in Biophysics and Molecular Biology. 138:59-68
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kashyap, B., Pegorsch, L., Frey, R.A., Sun, C., Shelden, E.A., and Stenkamp, D.L. (2014) Eye-specific gene expression following embryonic ethanol exposure in zebrafish: Roles for heat shock factor 1. Reproductive toxicology (Elmsford, N.Y.). 43:111-124
- Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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