Gene
acp5a
- ID
- ZDB-GENE-040426-2864
- Name
- acid phosphatase 5a, tartrate resistant
- Symbol
- acp5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable acid phosphatase activity; ferric iron binding activity; and ferrous iron binding activity. Predicted to be involved in bone resorption. Is expressed in several structures, including cranium; fin; hematopoietic system; scale; and yolk syncytial layer. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb576 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010828Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa16094 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17411 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40635 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Spondyloenchondrodysplasia with immune dysregulation | 607944 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Metallo-dependent phosphatase-like | Metallophosphoesterase Purple Acid Phosphatase | Purple acid phosphatase |
|---|---|---|---|---|---|
| UniProtKB:Q7SXT1 | InterPro | 339 | |||
| UniProtKB:A0AB32TUZ0 | InterPro | 320 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(acp5a:mNeonGreen-CAAX) |
|
| 1 | Saelens et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-276A17 | ZFIN Curated Data | |
| Encodes | EST | cb576 | ZFIN Curated Data | |
| Encodes | EST | fb19f01 | ZFIN Curated Data | |
| Encodes | EST | fb30b03 | ZFIN Curated Data | |
| Encodes | EST | fi14e01 | ZFIN Curated Data | |
| Encodes | EST | fj66f03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63825 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214773 (1) | 1690 nt | ||
| Genomic | GenBank:CR394534 (1) | 153370 nt | ||
| Polypeptide | UniProtKB:Q7SXT1 (1) | 339 aa |
- Breuer, M., Rummler, M., Singh, J., Maher, S., Zaouter, C., Jamadagni, P., Pilon, N., Willie, B.M., Patten, S.A. (2024) CHD7 regulates craniofacial cartilage development via controlling HTR2B expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 39(4):498-512
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Carletti, A., Rosa, J.T., Pes, K., Borges, I., Santos, T., Barreira, L., Varela, J., Pereira, H., Cancela, M.L., Gavaia, P.J., Laizé, V. (2023) The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and molecular life sciences : CMLS. 80:310310
- Daponte, V., Tonelli, F., Masiero, C., Syx, D., Exbrayat-Héritier, C., Biggiogera, M., Willaert, A., Rossi, A., Coucke, P.J., Ruggiero, F., Forlino, A. (2023) Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure. Matrix biology : journal of the International Society for Matrix Biology. 121:105-126
- Guo, W., Jin, P., Li, R., Huang, L., Liu, Z., Li, H., Zhou, T., Fang, B., Xia, L. (2023) Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Experimental & molecular medicine. 55(1):81-94
- Tonelli, F., Leoni, L., Daponte, V., Gioia, R., Cotti, S., Fiedler, I.A.K., Larianova, D., Willaert, A., Coucke, P.J., Villani, S., Busse, B., Besio, R., Rossi, A., Witten, P.E., Forlino, A. (2023) Zebrafish Tric-b is required for skeletal development and bone cells differentiation. Frontiers in endocrinology. 14:10029141002914
- Khrystoforova, I., Shochat-Carvalho, C., Harari, R., Henke, K., Woronowicz, K., Harris, M.P., Karasik, D. (2022) Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Frontiers in endocrinology. 13:985304
- Saelens, J.W., Sweeney, M.I., Viswanathan, G., Xet-Mull, A.M., Jurcic Smith, K.L., Sisk, D.M., Hu, D.D., Cronin, R.M., Hughes, E.J., Brewer, W.J., Coers, J., Champion, M.M., Champion, P.A., Lowe, C.B., Smith, C.M., Lee, S., Stout, J.E., Tobin, D.M. (2022) An ancestral mycobacterial effector promotes dissemination of infection. Cell. 185(24):4507-4525.e18
- Wang, F., Rong, P., Wang, J., Yu, X., Wang, N., Wang, S., Xue, Z., Chen, J., Meng, W., Peng, X. (2022) Anti-osteoporosis effects and regulatory mechanism of Lindera aggregata based on network pharmacology and experimental validation. Food & function. 13(11):6419-6432
- Xu, P., Lin, B., Deng, X., He, S., Chen, N., Wang, N. (2022) Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish. Journal of ethnopharmacology. 293:115269
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