Gene

hk1

ID
ZDB-GENE-040426-2848
Name
hexokinase 1
Symbol
hk1 Nomenclature History
Previous Names
  • DrHXK1 (1)
  • im:7148527
  • wu:fc09d08
  • wu:fc16e02
  • wu:fc21e02
  • wu:fq14b11
  • zgc:55790 (1)
  • zgc:77618
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have fructokinase activity; glucokinase activity; and mannokinase activity. Predicted to be involved in cellular glucose homeostasis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol and mitochondrion. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
29 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hk1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 4G Alliance Neuropathy, hereditary motor and sensory, Russe type 605285
Hemolytic anemia due to hexokinase deficiency 235700
Neurodevelopmental disorder with visual defects and brain anomalies 618547
Retinitis pigmentosa 79 617460
Associated With hk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR019807 Hexokinase, binding site
Domain IPR022672 Hexokinase, N-terminal
Domain IPR022673 Hexokinase, C-terminal
Family IPR001312 Hexokinase
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length ATPase, nucleotide binding domain Hexokinase Hexokinase, binding site Hexokinase, C-terminal Hexokinase, N-terminal
UniProtKB:Q7ZUM3 918
UniProtKB:A0A2R8RKK2 844
UniProtKB:Q6NX09 918
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations