Gene
usp25
- ID
- ZDB-GENE-040426-2847
- Name
- ubiquitin specific peptidase 25
- Symbol
- usp25 Nomenclature History
- Previous Names
-
- wu:fi33c05
- wu:fo67e06
- wu:fp97a04
- zgc:55791
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development and dorsal/ventral pattern formation. Predicted to be active in cytosol and nucleus. Orthologous to human USP25 (ubiquitin specific peptidase 25).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55791 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Epilepsy, idiopathic generalized, susceptibility to, 19} | 621064 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003903 | Ubiquitin interacting motif |
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Conserved_site | IPR054108 | Ubiquitin carboxyl-terminal hydrolase 25/28, UIM |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Domain | IPR054109 | UBA-like domain |
| Family | IPR044635 | Ubiquitin carboxyl-terminal hydrolase 14-like |
| Homologous_superfamily | IPR009060 | UBA-like superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | UBA-like domain | UBA-like superfamily | Ubiquitin carboxyl-terminal hydrolase 14-like | Ubiquitin carboxyl-terminal hydrolase 25/28, UIM | Ubiquitin interacting motif | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVQ4 | InterPro | 1072 | |||||||||
| UniProtKB:A0A8M9QGK5 | InterPro | 1108 | |||||||||
| UniProtKB:A0A8M2BGH6 | InterPro | 1073 | |||||||||
| UniProtKB:A0A8M3AX40 | InterPro | 1165 | |||||||||
| UniProtKB:A0A0R4IQS2 | InterPro | 1162 | |||||||||
| UniProtKB:A0A8M3B6G9 | InterPro | 1166 | |||||||||
| UniProtKB:A0A8M2BGE7 | InterPro | 1163 | |||||||||
| UniProtKB:A0A8M3B3I3 | InterPro | 1165 | |||||||||
| UniProtKB:A0A8M3BD95 | InterPro | 1076 |
Interactions and Pathways
No data available
Plasmids